6SIT

Pseudo-atomic crystal structure of the desmoglein 2 - human adenovirus serotype 3 fibre knob complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Virus attachment protein globular domain	8033000	3001376	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Cadherin-like	8091815	3002049	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Cadherin-like	8091816	3002049	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adeno_knob	e6sitA1	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Adeno_knob	ECOD (1.6)
B [auth D]	Cadherin	e6sitD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Cadherin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00541	Adenoviral fibre protein (knob domain) (Adeno_knob)	Adenoviral fibre protein (knob domain)	Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal kn ...	Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.	Domain
B [auth D]	PF00028	Cadherin domain (Cadherin)	Cadherin domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fiber protein	-	virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host adhesion receptor-mediated virion attachment to host cell biological process involved in interaction with host biological process involved in symbiotic interaction cell adhesion cellular process symbiont entry into host cell symbiont entry into host	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle
B [auth D]	Desmoglein-2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cell adhesion molecule binding protein binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cell adhesion mediator activity cell-cell adhesion mediator activity protein binding involved in heterotypic cell-cell adhesion	cellular component organization cell junction organization desmosome organization cellular process cellular component organization or biogenesis cell-cell junction organization response to ketone response to lipid response to stimulus response to hormone response to steroid hormone response to chemical response to endogenous stimulus response to progesterone cellular component organization cell junction organization desmosome organization cellular process cellular component organization or biogenesis cell-cell junction organization response to ketone response to lipid response to stimulus response to hormone response to steroid hormone response to chemical response to endogenous stimulus response to progesterone response to oxygen-containing compound multi-multicellular organism process multicellular organismal process maternal process involved in female pregnancy reproductive process multicellular organismal reproductive process female pregnancy multi-organism reproductive process heart process system process regulation of heart contraction regulation of system process homotypic cell-cell adhesion cell communication heterotypic cell-cell adhesion cell adhesion circulatory system process cell-cell adhesion regulation of multicellular organismal process cell communication involved in cardiac conduction blood circulation bundle of His cell to Purkinje myocyte communication regulation of biological process cardiac muscle cell-cardiac muscle cell adhesion biological regulation regulation of blood circulation cardiac conduction bundle of His cell-Purkinje myocyte adhesion involved in cell communication heart contraction regulation of actin filament-based process regulation of cellular process cardiac muscle cell action potential involved in contraction regulation of ventricular cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction regulation of cardiac muscle cell action potential actin filament-based process regulation of biological quality cardiac muscle cell contraction regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction action potential actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction cardiac muscle cell action potential regulation of membrane potential developmental process heart development cardiac conduction system development cardiac muscle tissue development animal organ development Purkinje myocyte development tissue development striated muscle tissue development circulatory system development multicellular organism development ventricular cardiac muscle tissue development anatomical structure development muscle tissue development His-Purkinje system development system development cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules regulation of heart rate by cardiac conduction regulation of heart rate	cellular anatomical structure cell junction cell periphery plasma membrane membrane cornified envelope cell-cell junction anchoring junction apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure cell junction cell periphery plasma membrane membrane cornified envelope cell-cell junction anchoring junction apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle desmosome lateral plasma membrane intercalated disc cell-cell contact zone

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009013	Attachment protein shaft domain superfamily	Homologous Superfamily
A	IPR000978	Adenoviral fibre protein, knob	Domain
A	IPR008982	Adenovirus pIV-like, attachment domain	Homologous Superfamily
A	IPR000931	Adenovirus fibre protein	Family
A	IPR000939	Adenoviral fibre protein, repeat/shaft region	Repeat
B [auth D]	IPR027397	Catenin binding domain superfamily	Homologous Superfamily
B [auth D]	IPR015919	Cadherin-like superfamily	Homologous Superfamily
B [auth D]	IPR009122	Desmosomal cadherin	Family
B [auth D]	IPR020894	Cadherin conserved site	Conserved Site
B [auth D]	IPR050971	Cadherin domain-containing protein	Family
B [auth D]	IPR002126	Cadherin-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth D]	Pharos: Q14126	arrhythmogenic right ventricular cardiomyopathy dilated cardiomyopathy 1BB arrhythmogenic right ventricular dysplasia 10 dilated cardiomyopathy cardiomyopathy lung adenocarcinoma malignant glioma MALT lymphoma non-small cell lung carcinoma palmoplantar keratosis acute myeloid leukemia primitive neuroectodermal tumor atypical teratoid rhabdoid tumor transitional cell carcinoma Charcot-Marie-Tooth disease arrhythmogenic right ventricular cardiomyopathy dilated cardiomyopathy 1BB arrhythmogenic right ventricular dysplasia 10 dilated cardiomyopathy cardiomyopathy lung adenocarcinoma malignant glioma MALT lymphoma non-small cell lung carcinoma palmoplantar keratosis acute myeloid leukemia primitive neuroectodermal tumor atypical teratoid rhabdoid tumor transitional cell carcinoma Charcot-Marie-Tooth disease esophageal adenocarcinoma familial isolated dilated cardiomyopathy interstitial cystitis lung cancer malignant mesothelioma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis breast cancer Conduction disorder of the heart facioscapulohumeral muscular dystrophy glioblastoma large cell medulloblastoma malignant ependymoma malignant pancreatic neoplasm nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pulmonary hypertension cystic fibrosis erythrokeratoderma familial dilated cardiomyopathy hypertrophic cardiomyopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.