6OF8

Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6of8b1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6of8b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6of8c1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6of8c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth G]	d6of8g1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth G]	d6of8g2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6of8e_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth A]	d6of8a1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth A]	d6of8a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth D]	d6of8d1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth D]	d6of8d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth F]	d6of8f_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)
F [auth A]	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)
A [auth F]	SCOP2B Superfamily	NTF2-like	8066423	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	SnoaL_3	e6of8B1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)
C	SnoaL_3	e6of8C1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)
D [auth G]	SnoaL_3	e6of8G1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)
E	SnoaL_3	e6of8E1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)
F [auth A]	SnoaL_3	e6of8A1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)
G [auth D]	SnoaL_3	e6of8D1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)
A [auth F]	SnoaL_3	e6of8F1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)
D [auth G]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)
E	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)
F [auth A]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)
G [auth D]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)
A [auth F]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	PF08332	Calcium/calmodulin dependent protein kinase II association domain (CaMKII_AD)	Calcium/calmodulin dependent protein kinase II association domain	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain i ...	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	Calcium/calmodulin-dependent protein kinase type II subunit alpha	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding glutamate receptor binding protein serine kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding glutamate receptor binding protein serine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein homodimerization activity protein dimerization activity calmodulin binding cation binding metal ion binding	membrane organization transport apoptotic mitochondrial changes biological regulation cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process membrane organization transport apoptotic mitochondrial changes biological regulation cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process cellular component organization or biogenesis regulation of biological quality regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport response to stimulus response to stress response to ischemia cellular response to nitrogen compound cellular response to stimulus response to angiotensin regulation of cellular process signaling response to peptide hormone angiotensin-activated signaling pathway cellular response to angiotensin cell communication cellular response to endogenous stimulus response to hormone signal transduction cellular response to hormone stimulus regulation of biological process response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical G protein-coupled receptor signaling pathway developmental process multicellular organismal process regulation of cell motility neuron migration cellular developmental process nervous system development regulation of neuron migration generation of neurons neurogenesis multicellular organism development cell differentiation regulation of locomotion anatomical structure development regulation of cell migration cell migration cell motility locomotion system development cellular response to interferon-beta response to peptide response to interferon-beta response to cytokine cellular response to cytokine stimulus regulation of signaling cannabinoid signaling pathway regulation of signal transduction endocannabinoid signaling pathway regulation of response to stimulus regulation of cell communication regulation of G protein-coupled receptor signaling pathway regulation of endocannabinoid signaling pathway positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of apoptotic process positive regulation of biological process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process positive regulation of cellular process protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of localization cellular localization modulation of chemical synaptic transmission synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling neurotransmitter transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling peptidyl-threonine autophosphorylation peptidyl-amino acid modification peptidyl-threonine modification peptidyl-threonine phosphorylation biological process involved in interspecies interaction between organisms immune response response to other organism defense response response to type II interferon defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of neuronal synaptic plasticity regulation of synaptic plasticity dendritic spine development plasma membrane bounded cell projection organization cell projection organization cell development neuron projection development neuron differentiation dendrite development neuron development regulation of calcium ion transport positive regulation of calcium ion transport regulation of monoatomic ion transport calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling peptidyl-serine modification peptidyl-serine phosphorylation negative regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity negative regulation of molecular function negative regulation of catalytic activity	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cell projection neuron projection plasma membrane bounded cell projection protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex intracellular protein-containing complex membrane intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle organelle membrane endocytic vesicle neuron spine synapse dendritic spine somatodendritic compartment postsynapse cell junction dendrite dendritic tree postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	IPR017441	Protein kinase, ATP binding site	Binding Site
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain	Domain
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	IPR000719	Protein kinase domain	Domain
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth F], B, C, D [auth G], E, A [auth F], B, C, D [auth G], E, F [auth A], G [auth D]	Pharos: Q9UQM7	Wilson disease Hyperalgesia cocaine abuse cocaine dependence intellectual disability, autosomal dominant 53 malignant ependymoma mast cell leukemia acute myeloid leukemia ovarian cancer bipolar disorder glioblastoma large cell medulloblastoma malignant glioma oligodendroglioma aggressive systemic mastocytosis Wilson disease Hyperalgesia cocaine abuse cocaine dependence intellectual disability, autosomal dominant 53 malignant ependymoma mast cell leukemia acute myeloid leukemia ovarian cancer bipolar disorder glioblastoma large cell medulloblastoma malignant glioma oligodendroglioma aggressive systemic mastocytosis pilocytic astrocytoma ulcerative colitis astrocytic tumor colorectal cancer intellectual disability major depressive disorder malignant mesothelioma medulloblastoma osteosarcoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor depressive disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.