6LR3 | pdb_00006lr3

Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6lr3a_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
B [auth C]	d6lr3c_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
C [auth D]	d6lr3d_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
D [auth B]	d6lr3b_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
E	d6lr3e_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
F	d6lr3f_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
G	d6lr3g_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
H	d6lr3h_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
I	d6lr3i_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
J	d6lr3j_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
K	d6lr3k_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
L	d6lr3l_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MIF	e6lr3A1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
B [auth C]	MIF	e6lr3C1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
C [auth D]	MIF	e6lr3D1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
D [auth B]	MIF	e6lr3B1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
E	MIF	e6lr3E1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
F	MIF	e6lr3F1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
G	MIF	e6lr3G1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
H	MIF	e6lr3H1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
I	MIF	e6lr3I1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
J	MIF	e6lr3J1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
K	MIF	e6lr3K1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
L	MIF	e6lr3L1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
B [auth C]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
C [auth D]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
D [auth B]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
E	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
F	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
G	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
H	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
I	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
J	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
K	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
L	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth D], D [auth B], E, A, B [auth C], C [auth D], D [auth B], E, F, G, H, I, J, K, L	PF01187	Macrophage migration inhibitory factor (MIF) (MIF)	Macrophage migration inhibitory factor (MIF)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth D], D [auth B], E, A, B [auth C], C [auth D], D [auth B], E, F, G, H, I, J, K, L	Macrophage migration inhibitory factor	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity phenylpyruvate tautomerase activity catalytic activity	-	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth D], D [auth B], E, A, B [auth C], C [auth D], D [auth B], E, F, G, H, I, J, K, L	IPR001398	Macrophage migration inhibitory factor	Family
A, B [auth C], C [auth D], D [auth B], E, A, B [auth C], C [auth D], D [auth B], E, F, G, H, I, J, K, L	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.