6LKV | pdb_00006lkv

Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d6lkva1	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
B [auth A]	d6lkva2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
D [auth C]	d6lkvc1	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	MIF-related	Microphage migration inhibition factor (MIF)	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)
D [auth C]	d6lkvc2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Oncomelania hupensis ) [TaxId: 56141 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	MIF	e6lkvA1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
C [auth B]	MIF	e6lkvB1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)
D [auth C]	MIF	e6lkvC1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: MIF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth F]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
B [auth A]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
C [auth B]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)
D [auth C]	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth F]	PF01187	Macrophage migration inhibitory factor (MIF) (MIF)	Macrophage migration inhibitory factor (MIF)		Domain
B [auth A]	PF01187	Macrophage migration inhibitory factor (MIF) (MIF)	Macrophage migration inhibitory factor (MIF)		Domain
C [auth B]	PF01187	Macrophage migration inhibitory factor (MIF) (MIF)	Macrophage migration inhibitory factor (MIF)		Domain
D [auth C]	PF01187	Macrophage migration inhibitory factor (MIF) (MIF)	Macrophage migration inhibitory factor (MIF)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth F]	Macrophage migration inhibitory factor	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity phenylpyruvate tautomerase activity catalytic activity	-	cellular anatomical structure extracellular region extracellular space
B [auth A]	Macrophage migration inhibitory factor	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity phenylpyruvate tautomerase activity catalytic activity	-	cellular anatomical structure extracellular region extracellular space
C [auth B]	Macrophage migration inhibitory factor	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity phenylpyruvate tautomerase activity catalytic activity	-	cellular anatomical structure extracellular region extracellular space
D [auth C]	Macrophage migration inhibitory factor	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity signaling receptor activator activity protein binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity intramolecular oxidoreductase activity, interconverting keto- and enol-groups isomerase activity intramolecular oxidoreductase activity phenylpyruvate tautomerase activity catalytic activity	-	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth F]	IPR001398	Macrophage migration inhibitory factor	Family
A [auth F]	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily
B [auth A]	IPR001398	Macrophage migration inhibitory factor	Family
B [auth A]	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily
C [auth B]	IPR001398	Macrophage migration inhibitory factor	Family
C [auth B]	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily
D [auth C]	IPR001398	Macrophage migration inhibitory factor	Family
D [auth C]	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.