Annotations: 6IDX

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e6idxA3	A: alpha arrays	X: ELMO domain (From Topology)	H: ELMO domain (From Topology)	T: ELMO domain	F: UNK_F_TYPE	ECOD (1.6)
A	Drf_GBD	e6idxA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Drf_GBD	ECOD (1.6)
A	FERM_N	e6idxA1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: FERM_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04727	ELMO/CED-12 family (ELMO_CED12)	ELMO/CED-12 family	-	Family
A	PF11841	ELMO, armadillo-like helical domain (ELMO_ARM)	ELMO, armadillo-like helical domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Engulfment and cell motility protein 2	SH3 domain binding protein binding binding protein domain specific binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding	cell chemotaxis cellular response to stimulus chemotaxis response to stimulus response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cellular process cell motility locomotion localization import into cell cell chemotaxis cellular response to stimulus chemotaxis response to stimulus response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cellular process cell motility locomotion localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport apoptotic process cell death programmed cell death cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol
B [auth C]	Adhesion G protein-coupled receptor B1	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity protein binding binding PDZ domain binding protein domain specific binding lipid binding lipopolysaccharide binding carbohydrate derivative binding modified amino acid binding phospholipid binding phosphatidylserine binding	membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination positive regulation of nervous system development multicellular organismal process regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development regulation of multicellular organismal process regulation of synapse structure or activity synapse organization regulation of synapse assembly regulation of biological quality positive regulation of cellular process system development developmental process regulation of multicellular organismal development regulation of biological process positive regulation of cellular component biogenesis biological regulation nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process negative regulation of cellular process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus muscle structure development animal organ development muscle organ development cellular response to stimulus cell surface receptor signaling pathway signaling signal transduction cell communication negative regulation of locomotion regulation of cell motility endothelial cell migration negative regulation of endothelial cell migration regulation of locomotion regulation of cell migration regulation of endothelial cell migration negative regulation of cell motility cell migration cell motility locomotion negative regulation of cell migration regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of syncytium formation by plasma membrane fusion cellular developmental process cell-cell fusion muscle cell differentiation myotube differentiation cell differentiation syncytium formation positive regulation of myoblast fusion myoblast fusion regulation of myoblast fusion positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis striated muscle cell differentiation reactive oxygen species biosynthetic process regulation of biosynthetic process positive regulation of reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process positive regulation of metabolic process biosynthetic process positive regulation of biosynthetic process regulation of reactive oxygen species metabolic process defense response to Gram-negative bacterium defense response to bacterium response to bacterium catabolic process macromolecule catabolic process negative regulation of protein catabolic process negative regulation of catabolic process protein catabolic process regulation of catabolic process regulation of protein catabolic process angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis negative regulation of multicellular organismal process engulfment of apoptotic cell apoptotic cell clearance phagocytosis, recognition cell recognition	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell periphery plasma membrane membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell periphery plasma membrane membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection neuron spine synapse dendritic spine postsynapse postsynaptic density neuron to neuron synapse postsynaptic specialization organelle asymmetric synapse intracellular anatomical structure perinuclear region of cytoplasm cytoplasm phagocytic cup extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR006816	ELMO domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR050868	Engulfment and cell motility domain-containing protein	Family
A	IPR024574	ELMO, armadillo-like helical domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
B [auth C]	IPR032471	GAIN domain, N-terminal	Domain
B [auth C]	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
B [auth C]	IPR000832	GPCR, family 2, secretin-like	Family
B [auth C]	IPR000203	GPS motif	Conserved Site
B [auth C]	IPR017981	GPCR, family 2-like, 7TM	Domain
B [auth C]	IPR008077	GPCR, family 2, brain-specific angiogenesis inhibitor	Family
B [auth C]	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
B [auth C]	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
B [auth C]	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
B [auth C]	IPR043838	Adhesion G protein-coupled receptor B, N-terminal domain	Domain
B [auth C]	IPR046338	GAIN domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96JJ3	primary intraosseous venous malformation astrocytic tumor large cell medulloblastoma oligodendroglioma atypical teratoid rhabdoid tumor malignant ependymoma ovarian cancer Ramon syndrome esophageal adenocarcinoma medulloblastoma Pick disease subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.