6FPZ | pdb_00006fpz

Inter-alpha-inhibitor heavy chain 1, D298A

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e6fpzA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: UNK_F_TYPE	ECOD (1.6)
A	UNK_F_TYPE	e6fpzA1	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: UNK_F_TYPE	ECOD (1.6)
A	UNK_F_TYPE	e6fpzA3	A: alpha bundles	X: Four-helical up-and-down bundle	H: vWA2 C-terminal domain (From Topology)	T: vWA2 C-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
A	VWA	e6fpzA2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)
B	UNK_F_TYPE	e6fpzB4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6fpzB1	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6fpzB3	A: alpha bundles	X: Four-helical up-and-down bundle	H: vWA2 C-terminal domain (From Topology)	T: vWA2 C-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
B	VWA	e6fpzB2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08487	Vault protein inter-alpha-trypsin domain (VIT)	Vault protein inter-alpha-trypsin domain	-	Family
A, B	PF00092	von Willebrand factor type A domain (VWA)	von Willebrand factor type A domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Inter-alpha-trypsin inhibitor heavy chain H1	binding carbohydrate binding cation binding ion binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein serine hydrolase activity serine-type endopeptidase inhibitor activity hydrolase activity binding carbohydrate binding cation binding ion binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein serine hydrolase activity serine-type endopeptidase inhibitor activity hydrolase activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity molecular function inhibitor activity molecular function regulator activity serine-type peptidase activity serine-type endopeptidase activity catalytic activity endopeptidase activity glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding	hyaluronan metabolic process glycosaminoglycan metabolic process aminoglycan metabolic process carbohydrate derivative metabolic process metabolic process cellular process macromolecule metabolic process	cellular anatomical structure extracellular region extracellular space blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure cellular anatomical structure extracellular region extracellular space blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A, B	IPR050934	Inter-alpha-trypsin inhibitor heavy chain	Family
A, B	IPR010600	Inter-alpha-trypsin inhibitor heavy chain, C-terminal	Domain
A, B	IPR013694	VIT domain	Domain
A, B	IPR002035	von Willebrand factor, type A	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P19827	liver cancer attention deficit hyperactivity disorder, inattentive type bipolar I disorder liver neoplasm osteoarthritis, hip Unipolar Depression autism spectrum disorder endogenous depression major depressive disorder psoriasis bipolar disorder osteoarthritis schizophrenia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.