6DK1

Human sigma-1 receptor bound to (+)-pentazocine

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RmlC-like cupins	8093035	3001825	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RmlC-like cupins	8093035	3001825	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RmlC-like cupins	8093035	3001825	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ERG2_Sigma1R	e6dk1A2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
A	KOG4143_like	e6dk1A1	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: KOG4143_like	ECOD (1.6)
C	ERG2_Sigma1R	e6dk1C2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
C	KOG4143_like	e6dk1C1	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: KOG4143_like	ECOD (1.6)
B	ERG2_Sigma1R	e6dk1B1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
B	KOG4143_like	e6dk1B2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: KOG4143_like	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF04622	ERG2 and Sigma1 receptor like protein (ERG2_Sigma1R)	ERG2 and Sigma1 receptor like protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Sigma non-opioid intracellular receptor 1	molecular transducer activity G protein-coupled opioid receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity identical protein binding protein binding binding	multicellular organismal process regulation of cellular component organization regulation of cellular process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly regulation of postsynapse assembly cell junction assembly anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of synapse assembly multicellular organismal process regulation of cellular component organization regulation of cellular process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly regulation of postsynapse assembly cell junction assembly anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of synapse assembly regulation of biological quality system development developmental process regulation of biological process postsynapse organization postsynapse assembly biological regulation regulation of postsynapse organization nervous system development regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization cellular process synapse assembly localization transport macromolecule localization lipid localization lipid transport establishment of localization neuron apoptotic process regulation of apoptotic process regulation of programmed cell death cell death apoptotic process programmed cell death regulation of neuron apoptotic process protein-containing complex organization protein trimerization protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle nuclear outer membrane nuclear membrane nucleus organelle outer membrane endomembrane system organelle envelope bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network nuclear envelope outer membrane organelle membrane lipid droplet membraneless organelle intracellular membraneless organelle cytosol organelle inner membrane nuclear inner membrane anchoring junction growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection site of polarized growth glutamatergic synapse endoplasmic reticulum organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR006716	ERG2/sigma1 receptor-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q99720	amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 16 autosomal recessive distal spinal muscular atrophy 2 HIV infectious disease juvenile amyotrophic lateral sclerosis cocaine dependence Memory Disorders dissociative amnesia Charcot-Marie-Tooth disease visual epilepsy cocaine abuse neurodegenerative disease pancreatic ductal adenocarcinoma schizophrenia idiopathic scoliosis amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 16 autosomal recessive distal spinal muscular atrophy 2 HIV infectious disease juvenile amyotrophic lateral sclerosis cocaine dependence Memory Disorders dissociative amnesia Charcot-Marie-Tooth disease visual epilepsy cocaine abuse neurodegenerative disease pancreatic ductal adenocarcinoma schizophrenia idiopathic scoliosis malignant colon neoplasm frontotemporal dementia ovarian cancer hypertensive disorder intellectual disability learning disability rheumatoid arthritis amnestic disorder large cell medulloblastoma lung cancer

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.