6D5V

Ras:SOS:Ras in complex with a small molecule activator

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth Q]d6d5vq_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins cH-p21 Ras protein Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth R]d6d5vr1 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins cH-p21 Ras protein Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth R]d6d5vr2 Artifacts Tags Tags Tags N-terminal Tags Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth S]d6d5vs_ All alpha proteins Ras GEF Ras GEF Ras GEF Son of sevenless protein homolog 1 (sos-1) Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth Q]Rase6d5vQ1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
B [auth R]Rase6d5vR1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
C [auth S]RasGEFe6d5vS1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Ras GEF (From Topology)T: Ras GEFF: RasGEFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth Q]3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
B [auth R]3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
C [auth S]1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein Chain S, domain 1CATH (4.3.0)
C [auth S]1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein Chain S, domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth Q]PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain
B [auth R]PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain
C [auth S]PF00617RasGEF domain (RasGEF)RasGEF domain- Family
C [auth S]PF00618RasGEF N-terminal motif (RasGEF_N)RasGEF N-terminal motifA subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth Q]GTPase HRas
B [auth R]GTPase HRas
C [auth S]Son of sevenless homolog 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth Q]IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A [auth Q]IPR020849Small GTPase, Ras-typeFamily
A [auth Q]IPR005225Small GTP-binding domainDomain
A [auth Q]IPR001806Small GTPaseFamily
B [auth R]IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
B [auth R]IPR020849Small GTPase, Ras-typeFamily
B [auth R]IPR005225Small GTP-binding domainDomain
B [auth R]IPR001806Small GTPaseFamily
C [auth S]IPR000219Dbl homology (DH) domainDomain
C [auth S]IPR008937Ras-like guanine nucleotide exchange factorFamily
C [auth S]IPR019804Ras guanine-nucleotide exchange factor, conserved siteConserved Site
C [auth S]IPR036964Ras guanine-nucleotide exchange factor, catalytic domain superfamilyHomologous Superfamily
C [auth S]IPR035899Dbl homology (DH) domain superfamilyHomologous Superfamily
C [auth S]IPR023578Ras guanine nucleotide exchange factor domain superfamilyHomologous Superfamily
C [auth S]IPR055251SOS1/NGEF-like, PH domainDomain
C [auth S]IPR001849Pleckstrin homology domainDomain
C [auth S]IPR000651Ras-like guanine nucleotide exchange factor, N-terminalDomain
C [auth S]IPR011993PH-like domain superfamilyHomologous Superfamily
C [auth S]IPR001895Ras guanine-nucleotide exchange factors catalytic domainDomain
C [auth S]IPR009072Histone-foldHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth Q]Pharos:  P01112
B [auth R]Pharos:  P01112
C [auth S]Pharos:  Q07889