6CVK | pdb_00006cvk

Hepatitis B e-antigen in complex with scFv e13

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d6cvkb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
A [auth B]	d6cvkb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
B [auth A]	d6cvka1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
B [auth A]	d6cvka3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
C	d6cvkc_	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV (Hepatitis B virus ) [TaxId: 10407 ],	SCOPe (2.08)
D	d6cvkd_	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV (Hepatitis B virus ) [TaxId: 10407 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2 Family	Hepatitis B viral capsid (hbcag)	8086396	4001050	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Hepatitis B viral capsid (hbcag)	8086397	3000581	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086397	3000581	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	V-set_8	e6cvkB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
A [auth B]	V-set	e6cvkB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
B [auth A]	V-set_8	e6cvkA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
B [auth A]	V-set	e6cvkA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C	Hepatitis_core	e6cvkC1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)
D	Hepatitis_core	e6cvkD1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)
D	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF00906	Hepatitis core antigen (Hepatitis_core)	Hepatitis core antigen	The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA [1]. There is some experimental evidence to support this [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Single chain variable fragment (scFv) e13	-	-	-
C, D	Capsid protein	DNA binding binding nucleic acid binding structural molecule activity RNA binding	biological process involved in interspecies interaction between organisms viral penetration into host nucleus intracellular transport of virus viral process viral life cycle transport of virus biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host biological process involved in interaction with host microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus transport of viral material towards nucleus	host cellular component cellular anatomical structure host cell viral capsid icosahedral viral capsid T=4 icosahedral viral capsid virion component extracellular region host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR013195	Hepatitis B virus, capsid N-terminal	Domain
C, D	IPR036459	Viral capsid core domain supefamily, Hepatitis B virus	Homologous Superfamily
C, D	IPR002006	Hepatitis core antigen	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.