Annotations: 6CPK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6cpka_	All beta proteins	SH3-like barrel	SH3-domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SH3-domain	8067953	4000369	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SH3-domain	8067954	3000153	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e6cpkA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SH3 and multiple ankyrin repeat domains protein 3	SH3 domain binding protein binding binding protein domain specific binding signaling receptor complex adaptor activity protein-macromolecule adaptor activity synaptic receptor adaptor activity molecular adaptor activity signaling adaptor activity scaffold protein binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding cytoskeletal protein binding SH3 domain binding protein binding binding protein domain specific binding signaling receptor complex adaptor activity protein-macromolecule adaptor activity synaptic receptor adaptor activity molecular adaptor activity signaling adaptor activity scaffold protein binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding cytoskeletal protein binding actin binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling membrane organization protein localization cellular localization postsynapse organization AMPA glutamate receptor clustering glutamate receptor clustering neurotransmitter-gated ion channel clustering localization within membrane protein localization to membrane cellular component organization localization cell junction organization receptor clustering cellular macromolecule localization macromolecule localization cellular component organization or biogenesis synapse organization postsynaptic membrane organization behavior learning learning or memory cognition imitative learning auditory behavior vocal learning learned vocalization behavior or vocal learning response to mechanical stimulus response to external stimulus mechanosensory behavior response to auditory stimulus observational learning response to abiotic stimulus long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component biogenesis cellular component assembly actin filament bundle organization negative regulation of cellular process actin filament-based process negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of cellular component organization actin cytoskeleton organization negative regulation of cytoskeleton organization actin filament organization negative regulation of actin filament bundle assembly regulation of cellular component biogenesis regulation of organelle organization organelle organization negative regulation of organelle organization regulation of actin cytoskeleton organization actin filament bundle assembly regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization memory regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development cell development regulation of dendritic spine development neuron projection development positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development system development developmental process dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development regulation of cellular component size homeostatic process cell volume homeostasis negative regulation of cell volume cellular homeostasis regulation of cell size regulation of anatomical structure size intracellular signal transduction intracellular signaling cassette MAPK cascade plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis dendritic spine morphogenesis dendritic spine organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection organization NMDA glutamate receptor clustering guanylate kinase-associated protein clustering cell junction assembly synapse assembly forebrain development central nervous system neuron differentiation GABAergic neuron differentiation striatum development subpallium development striatal medium spiny neuron differentiation head development forebrain generation of neurons animal organ development brain development central nervous system development telencephalon development forebrain neuron differentiation regulation of synapse structure or activity regulation of cell projection organization regulation of postsynapse organization regulation of neuron projection development regulation of anatomical structure morphogenesis regulation of synapse organization regulation of dendritic spine morphogenesis regulation of plasma membrane bounded cell projection organization positive regulation of long-term synaptic potentiation synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission, glutamatergic brain morphogenesis animal organ morphogenesis adult behavior positive regulation of cellular component organization regulation of synapse structural plasticity positive regulation of synapse structural plasticity postsynaptic density organization organelle assembly postsynaptic specialization assembly postsynapse assembly excitatory synapse assembly postsynaptic specialization organization postsynaptic density assembly neuromuscular process neuromuscular process controlling balance glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway regulation of glutamate receptor signaling pathway biological process involved in intraspecies interaction between organisms social behavior negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication long-term synaptic depression regulation of long-term synaptic depression positive regulation of nervous system development regulation of long-term neuronal synaptic plasticity regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of cell differentiation positive regulation of long-term neuronal synaptic plasticity positive regulation of neurogenesis regulation of neuronal synaptic plasticity regulation of multicellular organismal development positive regulation of cell development positive regulation of multicellular organismal process vocalization behavior	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell projection neuron projection plasma membrane bounded cell projection neuron spine synapse dendritic spine somatodendritic compartment postsynapse cell junction dendrite cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell projection neuron projection plasma membrane bounded cell projection neuron spine synapse dendritic spine somatodendritic compartment postsynapse cell junction dendrite dendritic tree cell periphery plasma membrane membrane membrane-bounded organelle cilium ciliary membrane bounding membrane of organelle organelle plasma membrane region organelle membrane cell projection membrane postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR002110	Ankyrin repeat	Repeat
A	IPR001452	SH3 domain	Domain
A	IPR051569	SH3 and multiple ankyrin repeat domains protein	Family
A	IPR001660	Sterile alpha motif domain	Domain
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR041489	PDZ domain 6	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BYB0	Phelan-McDermid syndrome intellectual disability schizophrenia 15 autism schizophrenia autism spectrum disorder Language Development Disorders large cell medulloblastoma malignant glioma medulloblastoma non-small cell lung carcinoma astrocytic tumor pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma developmental disability Phelan-McDermid syndrome intellectual disability schizophrenia 15 autism schizophrenia autism spectrum disorder Language Development Disorders large cell medulloblastoma malignant glioma medulloblastoma non-small cell lung carcinoma astrocytic tumor pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma developmental disability lung adenocarcinoma oligodendroglioma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor breast carcinoma subependymal giant cell astrocytoma ductal breast carcinoma in situ interstitial cystitis malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma auditory perceptual disorders breast fibroadenoma glioblastoma invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.