6CH2 | pdb_00006ch2

Crystal structure of the cytoplasmic domain of FlhA and FliT-FliD complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	FlgN-like	8092872	3001299	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FlgN-like	8092872	3001299	SCOP2B (2022-06-29)
F	SCOP2 Family	Flagellar chaperone FliT-like	8059021	4005472	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	FlgN-like	8092872	3001299	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FHIPEP_2nd	e6ch2A1	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: FHIPEP_2nd	ECOD (1.6)
A	FHIPEP_1st_1	e6ch2A2	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: FHIPEP_1st_1	ECOD (1.6)
A	FHIPEP_1st	e6ch2A4	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: FHIPEP_1st	ECOD (1.6)
A	FHIPEP_3rd	e6ch2A3	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: FHIPEP_3rd	ECOD (1.6)
B	FHIPEP_2nd	e6ch2B2	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: FHIPEP_2nd	ECOD (1.6)
B	FHIPEP_1st_1	e6ch2B1	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: FHIPEP_1st_1	ECOD (1.6)
B	FHIPEP_1st	e6ch2B4	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: FHIPEP_1st	ECOD (1.6)
B	FHIPEP_3rd	e6ch2B3	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: FHIPEP_3rd	ECOD (1.6)
C	FHIPEP_2nd	e6ch2C4	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: FHIPEP_2nd	ECOD (1.6)
C	FHIPEP_1st_1	e6ch2C2	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: FHIPEP_1st_1	ECOD (1.6)
C	FHIPEP_1st	e6ch2C3	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: FHIPEP_1st	ECOD (1.6)
C	FHIPEP_3rd	e6ch2C1	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: FHIPEP_3rd	ECOD (1.6)
D	FliT	e6ch2D1	A: alpha bundles	X: Flagellar protein fliT (From Topology)	H: Flagellar protein fliT (From Topology)	T: Flagellar protein fliT	F: FliT	ECOD (1.6)
E	FliT	e6ch2E1	A: alpha bundles	X: Flagellar protein fliT (From Topology)	H: Flagellar protein fliT (From Topology)	T: Flagellar protein fliT	F: FliT	ECOD (1.6)
F	FliT	e6ch2F1	A: alpha bundles	X: Flagellar protein fliT (From Topology)	H: Flagellar protein fliT (From Topology)	T: Flagellar protein fliT	F: FliT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.60	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	FHIPEP family, domain 1	CATH (4.3.0)
B	3.40.30.60	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	FHIPEP family, domain 1	CATH (4.3.0)
C	3.40.30.60	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	FHIPEP family, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00771	FHIPEP family (FHIPEP)	FHIPEP family	-	Family
D, E, F	PF05400	Flagellar protein FliT (FliT)	Flagellar protein FliT	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Flagellar biosynthesis protein FlhA	-	organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly protein localization establishment of protein localization organelle assembly cell projection organization bacterial-type flagellum assembly membraneless organelle assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region localization secretion by cell protein transport cellular macromolecule localization macromolecule localization	cell periphery cellular anatomical structure plasma membrane membrane
D, E, F	Flagellar hook-associated protein 2,Flagellar protein FliT	-	cellular component organization bacterial-type flagellum organization organelle organization cell projection organization cellular process cellular component organization or biogenesis regulation of cellular component organization regulation of cellular process bacterial-type flagellum assembly negative regulation of biological process membraneless organelle assembly negative regulation of organelle assembly cellular component biogenesis cellular component assembly cellular component organization bacterial-type flagellum organization organelle organization cell projection organization cellular process cellular component organization or biogenesis regulation of cellular component organization regulation of cellular process bacterial-type flagellum assembly negative regulation of biological process membraneless organelle assembly negative regulation of organelle assembly cellular component biogenesis cellular component assembly negative regulation of cellular process negative regulation of cell projection organization regulation of bacterial-type flagellum assembly regulation of biological process organelle assembly negative regulation of cellular component organization regulation of cell projection assembly regulation of cell projection organization biological regulation regulation of cellular component biogenesis regulation of organelle organization negative regulation of organelle organization regulation of organelle assembly cell projection assembly negative regulation of bacterial-type flagellum assembly protein folding biosynthetic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation bacterial-type flagellum-dependent cell motility cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility cell adhesion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol bacterial-type flagellum filament cap cell projection organelle membraneless organelle bacterial-type flagellum filament bacterial-type flagellum extracellular region bacterial-type flagellum hook

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR042194	FHIPEP, domain 1	Homologous Superfamily
A, B, C	IPR042196	FHIPEP, domain 4	Homologous Superfamily
A, B, C	IPR006301	Flagellar biosynthesis protein FlhA	Family
A, B, C	IPR001712	Type III secretion system FHIPEP	Family
A, B, C	IPR042193	FHIPEP, domain 3	Homologous Superfamily
A, B, C	IPR025505	FHIPEP conserved site	Conserved Site
D, E, F	IPR008622	Flagellar protein FliT	Family
D, E, F	IPR040026	Flagellar hook-associated protein 2	Family
D, E, F	IPR010809	Flagellar hook-associated protein 2, C-terminal	Domain
D, E, F	IPR010810	Flagellin hook, IN motif	Conserved Site
D, E, F	IPR003481	Flagellar hook-associated protein 2, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.