6BJ5

Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	Serpins	8098489	4002658	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	Serpins	8098490	3001563	SCOP2 (2022-06-29)
C [auth A]	SCOP2B Superfamily	Serpins	8098490	3001563	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Serpins	8098490	3001563	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Serpin	e6bj5B1	A: a+b complex topology	X: Serpins (From Topology)	H: Serpins (From Topology)	T: Serpins	F: Serpin	ECOD (1.6)
C [auth A]	Serpin	e6bj5A1	A: a+b complex topology	X: Serpins (From Topology)	H: Serpins (From Topology)	T: Serpins	F: Serpin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], C [auth A], E [auth C]	PF00079	Serpin (serine protease inhibitor) (Serpin)	Serpin (serine protease inhibitor)	Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth F], D [auth G], F [auth H]	Serine proteinase inhibitor 1	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	multicellular organismal process response to stimulus regulation of response to external stimulus regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development regulation of response to wounding multicellular organism development tube morphogenesis vascular wound healing response to stress regulation of response to stress anatomical structure development multicellular organismal process response to stimulus regulation of response to external stimulus regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development regulation of response to wounding multicellular organism development tube morphogenesis vascular wound healing response to stress regulation of response to stress anatomical structure development regulation of multicellular organismal process response to wounding regulation of anatomical structure morphogenesis system development blood vessel development developmental process wound healing regulation of biological process regulation of multicellular organismal development negative regulation of response to stimulus blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of wound healing angiogenesis involved in wound healing biological regulation negative regulation of angiogenesis response to external stimulus negative regulation of response to wounding vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing anatomical structure formation involved in morphogenesis negative regulation of vascular wound healing negative regulation of multicellular organismal process regulation of vascular wound healing regulation of protein maturation negative regulation of plasminogen activation negative regulation of proteolysis regulation of cellular process negative regulation of protein maturation protein maturation regulation of primary metabolic process regulation of proteolysis proteolysis negative regulation of cellular process regulation of plasminogen activation protein metabolic process plasminogen activation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process zymogen activation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of protein processing protein processing metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of protein processing negative regulation of hydrolase activity regulation of catalytic activity negative regulation of catalytic activity negative regulation of peptidase activity negative regulation of molecular function regulation of peptidase activity regulation of molecular function regulation of hydrolase activity	cellular anatomical structure extracellular region extracellular space
A [auth B], C [auth A], E [auth C]	Serine proteinase inhibitor 1	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	multicellular organismal process response to stimulus regulation of response to external stimulus regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development regulation of response to wounding multicellular organism development tube morphogenesis vascular wound healing response to stress regulation of response to stress anatomical structure development multicellular organismal process response to stimulus regulation of response to external stimulus regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development regulation of response to wounding multicellular organism development tube morphogenesis vascular wound healing response to stress regulation of response to stress anatomical structure development regulation of multicellular organismal process response to wounding regulation of anatomical structure morphogenesis system development blood vessel development developmental process wound healing regulation of biological process regulation of multicellular organismal development negative regulation of response to stimulus blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of wound healing angiogenesis involved in wound healing biological regulation negative regulation of angiogenesis response to external stimulus negative regulation of response to wounding vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing anatomical structure formation involved in morphogenesis negative regulation of vascular wound healing negative regulation of multicellular organismal process regulation of vascular wound healing regulation of protein maturation negative regulation of plasminogen activation negative regulation of proteolysis regulation of cellular process negative regulation of protein maturation protein maturation regulation of primary metabolic process regulation of proteolysis proteolysis negative regulation of cellular process regulation of plasminogen activation protein metabolic process plasminogen activation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process zymogen activation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of protein processing protein processing metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of protein processing negative regulation of hydrolase activity regulation of catalytic activity negative regulation of catalytic activity negative regulation of peptidase activity negative regulation of molecular function regulation of peptidase activity regulation of molecular function regulation of hydrolase activity	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth F], D [auth G], F [auth H]	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily
B [auth F], D [auth G], F [auth H]	IPR023795	Serpin, conserved site	Conserved Site
B [auth F], D [auth G], F [auth H]	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily
B [auth F], D [auth G], F [auth H]	IPR036186	Serpin superfamily	Homologous Superfamily
B [auth F], D [auth G], F [auth H]	IPR000215	Serpin family	Family
B [auth F], D [auth G], F [auth H]	IPR023796	Serpin domain	Domain
A [auth B], C [auth A], E [auth C]	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily
A [auth B], C [auth A], E [auth C]	IPR023795	Serpin, conserved site	Conserved Site
A [auth B], C [auth A], E [auth C]	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily
A [auth B], C [auth A], E [auth C]	IPR036186	Serpin superfamily	Homologous Superfamily
A [auth B], C [auth A], E [auth C]	IPR000215	Serpin family	Family
A [auth B], C [auth A], E [auth C]	IPR023796	Serpin domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.