5YVG | pdb_00005yvg

Crystal structure of Karyopherin beta2 in complex with FUS(full length)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IBN_N	e5yvgA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)
B	IBN_N	e5yvgB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
A, B	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
A, B	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transportin-1	small GTPase binding protein binding binding enzyme binding GTPase binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity RNA binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus cellular process intracellular protein transport	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle
C [auth X], D [auth Y]	RNA-binding protein FUS	transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity chromatin binding binding molecular condensate scaffold activity transcription coactivator activity mRNA 3'-UTR binding RNA binding nucleic acid binding mRNA binding DNA binding cation binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity chromatin binding binding molecular condensate scaffold activity transcription coactivator activity mRNA 3'-UTR binding RNA binding nucleic acid binding mRNA binding DNA binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	cellular component biogenesis cellular component organization organelle organization cellular component assembly organelle assembly membraneless organelle assembly cellular process cellular component organization or biogenesis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process supramolecular fiber organization amyloid fibril formation cellular component biogenesis cellular component organization organelle organization cellular component assembly organelle assembly membraneless organelle assembly cellular process cellular component organization or biogenesis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process supramolecular fiber organization amyloid fibril formation regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process regulation of biological process negative regulation of metabolic process nucleobase-containing compound catabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of RNA metabolic process catabolic process positive regulation of biological process RNA metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process regulation of mRNA catabolic process positive regulation of biosynthetic process negative regulation of cellular process positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of catabolic process biological regulation negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of mRNA stability RNA stabilization negative regulation of biosynthetic process positive regulation of gene expression regulation of RNA stability regulation of mRNA metabolic process RNA splicing nucleobase-containing compound biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing cellular response to stimulus regulation of DNA recombination response to stimulus regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination DNA metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus regulation of DNA metabolic process DNA-templated transcription regulation of RNA biosynthetic process regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization regulation of RNA splicing	cytosolic region presynapse presynaptic cytosol cellular anatomical structure intracellular anatomical structure synapse cell junction cytoplasm cytosol intracellular organelle organelle membraneless organelle intracellular membraneless organelle membrane-bounded organelle cytosolic region presynapse presynaptic cytosol cellular anatomical structure intracellular anatomical structure synapse cell junction cytoplasm cytosol intracellular organelle organelle membraneless organelle intracellular membraneless organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen GABA-ergic synapse glutamatergic synapse postsynapse postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR040122	Importin beta family	Family
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR001494	Importin-beta, N-terminal domain	Domain
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR000357	HEAT repeat	Repeat
C [auth X], D [auth Y]	IPR034870	TAF15/EWS/TLS family	Family
C [auth X], D [auth Y]	IPR036443	Zinc finger, RanBP2-type superfamily	Homologous Superfamily
C [auth X], D [auth Y]	IPR000504	RNA recognition motif domain	Domain
C [auth X], D [auth Y]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
C [auth X], D [auth Y]	IPR001876	Zinc finger, RanBP2-type	Domain
C [auth X], D [auth Y]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q92973	malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma acne psoriasis atopic eczema subependymal giant cell astrocytoma chronic obstructive pulmonary disease esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma acne psoriasis atopic eczema subependymal giant cell astrocytoma chronic obstructive pulmonary disease esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma Alzheimer disease rheumatoid arthritis atrial fibrillation tuberculosis Crohn disease exocrine pancreatic carcinoma invasive ductal breast carcinoma lung cancer malignant glioma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease primitive neuroectodermal tumor astrocytic tumor Sjogren syndrome atypical teratoid rhabdoid tumor ulcerative colitis dermatomyositis glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma
C [auth X], D [auth Y]	Pharos: P35637	amyotrophic lateral sclerosis myxoid liposarcoma amyotrophic lateral sclerosis type 6 tremor, hereditary essential, 4 neurodegenerative disease juvenile amyotrophic lateral sclerosis Ewing sarcoma large cell medulloblastoma malignant ependymoma osteosarcoma acute myeloid leukemia pancreatic intraductal papillary-mucinous carcinoma AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) plasma cell myeloma astrocytic tumor amyotrophic lateral sclerosis myxoid liposarcoma amyotrophic lateral sclerosis type 6 tremor, hereditary essential, 4 neurodegenerative disease juvenile amyotrophic lateral sclerosis Ewing sarcoma large cell medulloblastoma malignant ependymoma osteosarcoma acute myeloid leukemia pancreatic intraductal papillary-mucinous carcinoma AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) plasma cell myeloma astrocytic tumor subependymal giant cell astrocytoma dementia Graves disease histiocytoma, Angiomatoid fibrous ovarian cancer adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis brain disease systemic lupus erythematosus essential tremor frontotemporal dementia with motor neuron disease Hashimoto thyroiditis lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome cancer gastric carcinoma hepatocellular carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.