5YJ0

Mouse Cereblon thalidomide binding domain complexed with S-form thalidomide


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AYippee-Mis18_1e5yj0A1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
B [auth D]Yippee-Mis18_1e5yj0D1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
C [auth G]Yippee-Mis18_1e5yj0G1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
D [auth J]Yippee-Mis18_1e5yj0J1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
E [auth M]Yippee-Mis18_1e5yj0M1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
F [auth P]Yippee-Mis18_1e5yj0P1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
G [auth S]Yippee-Mis18_1e5yj0S1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
H [auth V]Yippee-Mis18_1e5yj0V1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
I [auth Y]Yippee-Mis18_1e5yj0Y1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
J [auth b]Yippee-Mis18_1e5yj0b1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
K [auth e]Yippee-Mis18_1e5yj0e1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
L [auth h]Yippee-Mis18_1e5yj0h1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
M [auth k]Yippee-Mis18_1e5yj0k1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
N [auth n]Yippee-Mis18_1e5yj0n1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
O [auth q]Yippee-Mis18_1e5yj0q1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)
P [auth t]Yippee-Mis18_1e5yj0t1 A: beta complex topologyX: ETN0001 domain-like (From Homology)H: ETN0001 domain-likeT: Mss4-likeF: Yippee-Mis18_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
B [auth D]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
C [auth G]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
D [auth J]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
E [auth M]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
F [auth P]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
G [auth S]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
H [auth V]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
I [auth Y]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
J [auth b]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
K [auth e]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
L [auth h]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
M [auth k]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
N [auth n]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
O [auth q]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)
P [auth t]2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF03226Yippee zinc-binding/DNA-binding /Mis18, centromere assembly (Yippee-Mis18)Yippee zinc-binding/DNA-binding /Mis18, centromere assemblyThis family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Protein cereblon