5YD0 | pdb_00005yd0

Crystal structure of Schlafen 13 (SLFN13) N'-domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AlbA_2	e5yd0A2	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: AlbA_2	ECOD (1.6)
A	UNK_F_TYPE	e5yd0A1	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: UNK_F_TYPE	ECOD (1.6)
B	AlbA_2	e5yd0B2	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: AlbA_2	ECOD (1.6)
B	UNK_F_TYPE	e5yd0B1	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: UNK_F_TYPE	ECOD (1.6)
C	AlbA_2	e5yd0C1	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: AlbA_2	ECOD (1.6)
C	UNK_F_TYPE	e5yd0C2	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: UNK_F_TYPE	ECOD (1.6)
D	AlbA_2	e5yd0D2	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: AlbA_2	ECOD (1.6)
D	UNK_F_TYPE	e5yd0D1	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.950.30	Alpha Beta	2-Layer Sandwich	Methyltransferase, Cobalt-precorrin-4 Transmethylase	Domain 2	CATH (utative)
D	3.30.950.30	Alpha Beta	2-Layer Sandwich	Methyltransferase, Cobalt-precorrin-4 Transmethylase	Domain 2	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF17057	Poxviridae B3 protein (B3R)	Poxviridae B3 protein	-	Family
A, B, C, D	PF04326	Schlafen, AlbA_2 (SLFN_AlbA_2)	Schlafen, AlbA_2	This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important in cell differentiation and defense against viruses [1,2]. This domain is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence u ...	This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important in cell differentiation and defense against viruses [1,2]. This domain is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence unique to these proteins that may form a dimer interface [1]. The AlbA_2 domain is RNA-binding and RNase region as it contains the highly conserved catalytic glutamic acid residues [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Schlafen 8	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides ATP-dependent activity cation binding transition metal ion binding zinc ion binding metal ion binding RNA binding tRNA binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process tRNA metabolic process nucleobase-containing compound metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process tRNA metabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process tRNA decay RNA catabolic process regulation of cell cycle phase transition regulation of cellular process negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition biological regulation negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition DNA-templated DNA replication maintenance of fidelity regulation of primary metabolic process negative regulation of DNA-templated DNA replication negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process DNA-templated DNA replication negative regulation of DNA replication negative regulation of metabolic process DNA metabolic process regulation of macromolecule metabolic process DNA replication regulation of DNA-templated DNA replication replication fork arrest negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication rRNA catabolic process rRNA metabolic process biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle membraneless organelle site of DNA damage intracellular membraneless organelle chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR031450	Poxin-Schlafen/Schlafen-like, N-terminal domain	Domain
A, B, C, D	IPR029684	Schlafen family	Family
A, B, C, D	IPR018647	Schlafen group 3-like, DNA/RNA helicase domain	Domain
A, B, C, D	IPR007421	Schlafen, AlbA_2 domain	Domain
A, B, C, D	IPR048729	Schlafen, GTPase-like domain	Domain
A, B, C, D	IPR038461	Schlafen, AlbA_2 domain superfamily	Homologous Superfamily
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.