5X6E

Crystal structure of PrfA-DNA binary complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth M]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
A [auth M]	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
B [auth N]	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
B [auth N]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
E [auth A]	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
E [auth A]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
J [auth F]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
J [auth F]	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth M]	cNMP_binding	e5x6eM2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
A [auth M]	HTH_Crp_2	e5x6eM1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)
B [auth N]	cNMP_binding	e5x6eN2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
B [auth N]	HTH_Crp_2	e5x6eN1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)
E [auth A]	cNMP_binding	e5x6eA2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
E [auth A]	HTH_Crp_2	e5x6eA1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)
F [auth B]	cNMP_binding	e5x6eB2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
F [auth B]	HTH_Crp_2	e5x6eB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)
I [auth E]	cNMP_binding	e5x6eE1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
I [auth E]	HTH_Crp_2	e5x6eE2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)
J [auth F]	cNMP_binding	e5x6eF1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
J [auth F]	HTH_Crp_2	e5x6eF2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth M]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
A [auth M]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B [auth N]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B [auth N]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
E [auth A]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
E [auth A]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
F [auth B]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
F [auth B]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
I [auth E]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
I [auth E]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
J [auth F]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
J [auth F]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	Listeriolysin positive regulatory factor A	DNA binding binding organic cyclic compound binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol
C [auth O], G [auth C], K [auth G]	DNA (29-MER)	-	-	-
D [auth P], H [auth D], L [auth H]	DNA (28-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	IPR018335	Transcription regulator HTH, Crp-type, conserved site	Conserved Site
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	IPR012318	Crp-type HTH domain	Domain
A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], A [auth M], B [auth N], E [auth A], F [auth B], I [auth E], J [auth F]	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.