5O99

Unconventional SH3 domain from the postsynaptic density scaffold protein Shank3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d5o99b1	All beta proteins	SH3-like barrel	SH3-domain	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A [auth B]	d5o99b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth A]	d5o99a1	All beta proteins	SH3-like barrel	SH3-domain	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth A]	d5o99a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	SH3-domain	8067951	4000369	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	SH3-domain	8067952	3000153	SCOP2 (2022-06-29)
B [auth A]	SCOP2B Superfamily	SH3-domain	8067952	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	SH3_1	e5o99B1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
B [auth A]	SH3_1	e5o99A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
B [auth A]	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	SH3 and multiple ankyrin repeat domains protein 3	structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization SH3 domain binding protein binding binding protein domain specific binding signaling receptor complex adaptor activity protein-macromolecule adaptor activity synaptic receptor adaptor activity molecular adaptor activity signaling adaptor activity structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization SH3 domain binding protein binding binding protein domain specific binding signaling receptor complex adaptor activity protein-macromolecule adaptor activity synaptic receptor adaptor activity molecular adaptor activity signaling adaptor activity protein-containing complex binding identical protein binding scaffold protein binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding cytoskeletal protein binding actin binding G protein-coupled receptor binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling developmental process morphogenesis of embryonic epithelium embryonic epithelial tube formation epithelium development tube development embryonic morphogenesis morphogenesis of an epithelium tube formation tissue development embryo development epithelial tube formation tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis epithelial tube morphogenesis membrane organization protein localization cellular localization postsynapse organization AMPA glutamate receptor clustering glutamate receptor clustering neurotransmitter-gated ion channel clustering localization within membrane protein localization to membrane cellular component organization localization cell junction organization receptor clustering cellular macromolecule localization macromolecule localization cellular component organization or biogenesis synapse organization postsynaptic membrane organization behavior learning learning or memory cognition imitative learning auditory behavior vocal learning learned vocalization behavior or vocal learning response to mechanical stimulus response to external stimulus mechanosensory behavior response to auditory stimulus observational learning response to abiotic stimulus exploration behavior long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component biogenesis cellular component assembly actin filament bundle organization negative regulation of cellular process actin filament-based process negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of cellular component organization actin cytoskeleton organization negative regulation of cytoskeleton organization actin filament organization negative regulation of actin filament bundle assembly regulation of cellular component biogenesis regulation of organelle organization organelle organization negative regulation of organelle organization regulation of actin cytoskeleton organization actin filament bundle assembly regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization response to peptide response to chemical response to interleukin-17 response to cytokine memory regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development cell development regulation of dendritic spine development neuron projection development positive regulation of developmental process neurogenesis neuron differentiation dendrite development cell differentiation system development dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development regulation of behavior regulation of grooming behavior grooming behavior regulation of cellular component size homeostatic process cell volume homeostasis negative regulation of cell volume cellular homeostasis regulation of cell size regulation of anatomical structure size intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of localization regulation of protein localization regulation of AMPA glutamate receptor clustering regulation of receptor clustering regulation of protein localization to membrane regulation of glutamate receptor clustering regulation of cellular localization plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis dendritic spine morphogenesis dendritic spine organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation neuron projection organization NMDA glutamate receptor clustering guanylate kinase-associated protein clustering cell junction assembly synapse assembly regulation of postsynapse organization regulation of synapse organization regulation of synapse structure or activity forebrain development central nervous system neuron differentiation GABAergic neuron differentiation striatum development subpallium development striatal medium spiny neuron differentiation head development forebrain generation of neurons animal organ development brain development central nervous system development telencephalon development forebrain neuron differentiation locomotory behavior regulation of cell projection organization regulation of neuron projection development regulation of anatomical structure morphogenesis regulation of dendritic spine morphogenesis regulation of plasma membrane bounded cell projection organization positive regulation of long-term synaptic potentiation synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission, glutamatergic regulation of defense response behavioral fear response defense response regulation of fear response multicellular organismal response to stress regulation of behavioral fear response behavioral defense response fear response regulation of response to stress response to stress brain morphogenesis animal organ morphogenesis adult behavior positive regulation of cellular component organization regulation of synapse structural plasticity positive regulation of synapse structural plasticity postsynaptic density organization organelle assembly postsynaptic specialization assembly postsynapse assembly excitatory synapse assembly postsynaptic specialization organization postsynaptic density assembly neuromuscular process neuromuscular process controlling balance locomotory exploration behavior glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway regulation of glutamate receptor signaling pathway locomotion biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process cell population proliferation neural precursor cell proliferation biological process involved in intraspecies interaction between organisms social behavior negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication long-term synaptic depression regulation of long-term synaptic depression associative learning positive regulation of nervous system development regulation of long-term neuronal synaptic plasticity regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of cell differentiation positive regulation of long-term neuronal synaptic plasticity positive regulation of neurogenesis regulation of neuronal synaptic plasticity regulation of multicellular organismal development positive regulation of cell development positive regulation of multicellular organismal process vocalization behavior gliogenesis glial cell proliferation	cellular anatomical structure intracellular anatomical structure cytoplasm synapse cell junction glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection neuron spine dendritic spine somatodendritic compartment postsynapse dendrite cellular anatomical structure intracellular anatomical structure cytoplasm synapse cell junction glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection neuron spine dendritic spine somatodendritic compartment postsynapse dendrite dendritic tree postsynaptic density, intracellular component postsynaptic specialization intracellular membraneless organelle postsynaptic specialization, intracellular component intracellular organelle postsynaptic density neuron to neuron synapse organelle membraneless organelle asymmetric synapse cell periphery plasma membrane membrane membrane-bounded organelle cilium ciliary membrane bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR002110	Ankyrin repeat	Repeat
A [auth B], B [auth A]	IPR001452	SH3 domain	Domain
A [auth B], B [auth A]	IPR051569	SH3 and multiple ankyrin repeat domains protein	Family
A [auth B], B [auth A]	IPR001660	Sterile alpha motif domain	Domain
A [auth B], B [auth A]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR041489	PDZ domain 6	Domain
A [auth B], B [auth A]	IPR036034	PDZ superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.