5MJY | pdb_00005mjy

Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain (SARA complex structure)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	BRO1	e5mjyA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: BRO1	ECOD (1.6)
B	BRO1	e5mjyB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: BRO1	ECOD (1.6)
C	BRO1	e5mjyC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: BRO1	ECOD (1.6)
D	BRO1	e5mjyD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: BRO1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.280	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	alix/aip1 like domains	CATH (4.3.0)
B	1.25.40.280	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	alix/aip1 like domains	CATH (4.3.0)
C	1.25.40.280	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	alix/aip1 like domains	CATH (4.3.0)
D	1.25.40.280	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	alix/aip1 like domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03097	BRO1-like domain (BRO1)	BRO1-like domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Tyrosine-protein phosphatase non-receptor type 23	phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity protein binding binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity protein binding binding kinase binding enzyme binding protein kinase binding protein tyrosine phosphatase activity, metal-dependent	adherens junction organization regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization biological regulation positive regulation of biological process cellular component organization regulation of adherens junction organization cell junction organization cellular process cellular component organization or biogenesis positive regulation of cellular process positive regulation of adherens junction organization adherens junction organization regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization biological regulation positive regulation of biological process cellular component organization regulation of adherens junction organization cell junction organization cellular process cellular component organization or biogenesis positive regulation of cellular process positive regulation of adherens junction organization cell-cell junction organization catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process protein metabolic process positive regulation of homophilic cell adhesion regulation of homophilic cell adhesion positive regulation of cell adhesion regulation of cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly cilium organization cell projection assembly protein localization positive regulation of cell communication regulation of localization establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization cell communication localization cellular macromolecule localization positive regulation of Wnt protein secretion establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion positive regulation of protein localization cellular localization regulation of protein localization signaling transport positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport secretion by cell regulation of secretion by cell positive regulation of secretion signal release regulation of Wnt protein secretion regulation of signaling secretion regulation of transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport Wnt protein secretion positive regulation of protein secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization regulation of cell communication positive regulation of signaling multicellular organismal process negative regulation of locomotion regulation of cell motility negative regulation of biological process tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration negative regulation of cellular process regulation of multicellular organismal process cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion negative regulation of cell migration epithelium migration regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process establishment of protein localization to vacuole vesicle-mediated transport late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway establishment of localization in cell endosome transport via multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein localization to vacuole intracellular transport endosomal transport establishment of protein localization to organelle multivesicular body sorting pathway protein localization to organelle vacuolar transport intracellular protein transport positive regulation of early endosome to late endosome transport positive regulation of intracellular transport regulation of intracellular transport regulation of vesicle-mediated transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle cytoplasm nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen early endosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle nuclear body intracellular membraneless organelle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton
E, F	Zinc finger FYVE domain-containing protein 9	protein binding binding protein domain specific binding 1-phosphatidylinositol binding phospholipid binding lipid binding phosphatidylinositol binding cation binding ion binding metal ion binding small molecule binding	localization cellular localization transport establishment of localization in cell cellular process intracellular transport establishment of localization vesicle-mediated transport endosomal transport import into cell endocytosis cellular response to stimulus regulation of biological process cellular response to growth factor stimulus localization cellular localization transport establishment of localization in cell cellular process intracellular transport establishment of localization vesicle-mediated transport endosomal transport import into cell endocytosis cellular response to stimulus regulation of biological process cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling cellular response to transforming growth factor beta stimulus response to endogenous stimulus biological regulation cell communication cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway signal transduction enzyme-linked receptor protein signaling pathway	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane cytosol protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004328	BRO1 domain	Domain
A, B, C, D	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A, B, C, D	IPR025304	ALIX V-shaped domain	Domain
A, B, C, D	IPR038499	BRO1 domain superfamily	Homologous Superfamily
A, B, C, D	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B, C, D	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B, C, D	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A, B, C, D	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
E, F	IPR024608	Smad anchor for receptor activation-like, Smad-binding domain	Domain
E, F	IPR017455	Zinc finger, FYVE-related	Domain
E, F	IPR035438	Zinc finger FYVE domain containing protein, SARA/endofin	Family
E, F	IPR037145	Smad anchor for receptor activation, Smad-binding domain superfamily	Homologous Superfamily
E, F	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
E, F	IPR000306	FYVE zinc finger	Domain
E, F	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
E, F	IPR022557	Smad anchor for receptor activation-like, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9H3S7	epilepsy microcephaly Epileptic encephalopathy osteosarcoma intellectual disability
E, F	Pharos: O95405	atypical teratoid rhabdoid tumor large cell medulloblastoma malignant mesothelioma glioblastoma lung adenocarcinoma osteosarcoma interstitial cystitis malignant glioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.