5MHK | pdb_00005mhk

ICP4 DNA-binding domain in complex with 19mer DNA duplex from its own promoter

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	UNK_F_TYPE	e5mhkA1	A: alpha arrays	X: ICP4 DNA-binding domain (From Topology)	H: ICP4 DNA-binding domain (From Topology)	T: ICP4 DNA-binding domain	F: UNK_F_TYPE	ECOD (1.6)
F [auth C]	UNK_F_TYPE	e5mhkC1	A: alpha arrays	X: ICP4 DNA-binding domain (From Topology)	H: ICP4 DNA-binding domain (From Topology)	T: ICP4 DNA-binding domain	F: UNK_F_TYPE	ECOD (1.6)
G [auth D]	UNK_F_TYPE	e5mhkD1	A: alpha arrays	X: ICP4 DNA-binding domain (From Topology)	H: ICP4 DNA-binding domain (From Topology)	T: ICP4 DNA-binding domain	F: UNK_F_TYPE	ECOD (1.6)
H [auth B]	UNK_F_TYPE	e5mhkB1	A: alpha arrays	X: ICP4 DNA-binding domain (From Topology)	H: ICP4 DNA-binding domain (From Topology)	T: ICP4 DNA-binding domain	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth C], G [auth D], H [auth B]	PF03584	Herpesvirus ICP4-like protein N-terminal region (Herpes_ICP4_N)	Herpesvirus ICP4-like protein N-terminal region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G], C [auth E]	DNA (5'-D(GPCPTPCPCPGPTPGPTPGPGPAPCPGPAPTPCPGP*G)-3')	-	-	-
B [auth H], D [auth F]	DNA (5'-D(GPCPTPCPCPGPTPGPTPGPGPAPCPGPAPTPCPGP*G)-3')	-	-	-
E [auth A], F [auth C], G [auth D], H [auth B]	RS1	DNA binding binding nucleic acid binding	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to peptide response to chemical immune system process defense response to other organism response to stress innate immune response biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to peptide response to chemical immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus response to type I interferon viral gene expression DNA-templated viral transcription viral process viral transcription regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process cellular process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm virion component viral tegument
I [auth J]	ICP4 DNA BINDING DOMAIN	DNA binding binding nucleic acid binding	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to peptide response to chemical immune system process defense response to other organism response to stress innate immune response biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to peptide response to chemical immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus response to type I interferon viral gene expression DNA-templated viral transcription viral process viral transcription regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process cellular process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm virion component viral tegument

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth C], G [auth D], H [auth B]	IPR051425	Formin Homology	Family
E [auth A], F [auth C], G [auth D], H [auth B]	IPR005206	Herpesvirus ICP4-like protein, N-terminal	Domain
E [auth A], F [auth C], G [auth D], H [auth B]	IPR005205	Herpesvirus ICP4-like protein, C-terminal	Domain
I [auth J]	IPR051425	Formin Homology	Family
I [auth J]	IPR005206	Herpesvirus ICP4-like protein, N-terminal	Domain
I [auth J]	IPR005205	Herpesvirus ICP4-like protein, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.