5J28

Ki67-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5j28a_	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5j28b_	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metallo-dependent phosphatases	8034479	3001067	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metallo-dependent phosphatases	8034479	3001067	SCOP2B (2022-06-29)
C	SCOP2 Family	Ki-67/RepoMan PP1 interaction domain-like	8051061	4007178	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Ki-67/RepoMan PP1 interaction domain-like	8102235	3002725	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Ki-67/RepoMan PP1 interaction domain-like	8102235	3002725	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Metallophos_2_1	e5j28A1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
B	Metallophos_2_1	e5j28B1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
B	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A, B	PF16891	Serine-threonine protein phosphatase N-terminal domain (STPPase_N)	Serine-threonine protein phosphatase N-terminal domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	protein binding binding protein domain specific binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity RNA binding organic cyclic compound binding nucleic acid binding protein binding binding protein domain specific binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity RNA binding organic cyclic compound binding nucleic acid binding myosin phosphatase activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding kinase binding protein kinase binding protein-containing complex binding lamin binding cation binding ion binding metal ion binding small molecule binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation rhythmic process regulation of biological process circadian rhythm biological regulation regulation of circadian rhythm cellular process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation rhythmic process regulation of biological process circadian rhythm biological regulation regulation of circadian rhythm cellular process cell division protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of localization cellular localization regulation of cellular process nucleocytoplasmic transport transport regulation of transport nuclear transport regulation of nucleocytoplasmic transport intracellular transport establishment of localization localization regulation of cellular localization establishment of localization in cell regulation of intracellular transport multicellular organismal process cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development system development mitotic nuclear division organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation cellular component organization or biogenesis cell cycle chromosome segregation cell cycle process regulation of biosynthetic process circadian regulation of gene expression regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction response to light stimulus entrainment of circadian clock response to external stimulus photoperiodism response to radiation response to abiotic stimulus entrainment of circadian clock by photoperiod positive regulation of nervous system development regulation of developmental process positive regulation of cell population proliferation positive regulation of biological process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process regulation of glial cell proliferation gliogenesis positive regulation of cell differentiation regulation of multicellular organismal process positive regulation of neurogenesis positive regulation of cellular process regulation of multicellular organismal development cell population proliferation positive regulation of cell development regulation of cell population proliferation positive regulation of multicellular organismal process glial cell proliferation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development blastocyst development carbohydrate metabolic process energy derivation by oxidation of organic compounds glycogen metabolic process generation of precursor metabolites and energy glucan metabolic process polysaccharide metabolic process energy reserve metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle midbody anchoring junction cell junction focal adhesion cell-substrate junction nucleus membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle midbody anchoring junction cell junction focal adhesion cell-substrate junction nucleus membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen phosphatase complex protein-containing complex protein phosphatase type 1 complex catalytic complex protein serine/threonine phosphatase complex PTW/PP1 phosphatase complex nuclear speck nuclear body nucleoplasm cytosol presynapse synapse cell division site cell periphery cleavage furrow membrane plasma membrane plasma membrane region glutamatergic synapse chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree microtubule organizing center cytoskeleton microtubule cytoskeleton mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane
C, D	Antigen KI-67	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding RNA binding	regulation of chromosome segregation regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation cellular process cell cycle regulation of cell cycle chromosome segregation cell cycle process mitotic nuclear division regulation of cellular component organization organelle fission regulation of mitotic nuclear division regulation of chromosome segregation regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation cellular process cell cycle regulation of cell cycle chromosome segregation cell cycle process mitotic nuclear division regulation of cellular component organization organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle cellular component organization regulation of mitotic cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cellular component organization or biogenesis cell population proliferation regulation of chromatin organization chromatin organization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane chromosome nuclear body nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050341	Serine/threonine-protein phosphatase PP1 catalytic subunit	Family
A, B	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A, B	IPR031675	Serine-threonine protein phosphatase, N-terminal	Domain
A, B	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A, B	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
C, D	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
C, D	IPR000253	Forkhead-associated (FHA) domain	Domain
C, D	IPR012568	KI67R	Repeat
C, D	IPR029334	Protein phosphatase 1 binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P36873	ovarian cancer lung cancer lymphoplasmacytic lymphoma ovarian neoplasm Malignant neoplasm of ovary plasma cell myeloma
C, D	Pharos: P46013	psoriasis mesenchymal chondrosarcoma malignant colon neoplasm granular cell carcinoma lung adenocarcinoma adenocarcinoma breast carcinoma ovarian cancer peripheral nervous system disease colorectal cancer Copper-Overload Cirrhosis peripheral neuropathy tubular adenocarcinoma breast cancer ductal breast carcinoma in situ psoriasis mesenchymal chondrosarcoma malignant colon neoplasm granular cell carcinoma lung adenocarcinoma adenocarcinoma breast carcinoma ovarian cancer peripheral nervous system disease colorectal cancer Copper-Overload Cirrhosis peripheral neuropathy tubular adenocarcinoma breast cancer ductal breast carcinoma in situ pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor hepatocellular carcinoma pustulosis palmaris et plantaris invasive ductal breast carcinoma ulcerative colitis malignant ependymoma atypical teratoid rhabdoid tumor colonic neoplasm cribriform carcinoma of breast pancreatic intraductal papillary-mucinous carcinoma endometriosis hepatitis IgA glomerulonephritis spina bifida large cell medulloblastoma lung cancer malignant glioma adrenal cortex carcinoma benign colon neoplasm non-small cell lung carcinoma ovarian neoplasm pancreatic intraductal papillary-mucinous neoplasm glioblastoma interstitial cystitis atopic eczema malignant mesothelioma malignant pancreatic neoplasm medulloblastoma colorectal carcinoma osteosarcoma cribriform carcinoma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.