5BMU

The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G	GST_C_3	e5bmuG1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
A	GST_C_3	e5bmuA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
C	GST_C_3	e5bmuC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
E	GST_C_3	e5bmuE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
B	GST_C_3	e5bmuB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
D	GST_C_3	e5bmuD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
F	GST_C_3	e5bmuF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
H	GST_C_3	e5bmuH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G	3.40.30.90	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin		CATH (4.3.0)
G	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
A	3.40.30.90	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin		CATH (4.3.0)
A	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
C	3.40.30.90	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin		CATH (4.3.0)
C	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
E	3.40.30.90	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin		CATH (4.3.0)
E	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
B	1.20.1050.130	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
D	1.20.1050.130	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
F	1.20.1050.130	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
H	1.20.1050.130	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF21972	Nuclear-export cofactor Arc1p (Arc1p_N_like)	Nuclear-export cofactor Arc1p	This is the N-terminal domain of nuclear-export cofactor Arc1p (Arc1p-N). Arc1p-N and GluRS-N are known to be necessary and sufficient for formation of the yeast aaRS complex in vivo and in vitro. They are likely to form a stable complex with each ot ...	This is the N-terminal domain of nuclear-export cofactor Arc1p (Arc1p-N). Arc1p-N and GluRS-N are known to be necessary and sufficient for formation of the yeast aaRS complex in vivo and in vitro. They are likely to form a stable complex with each other. Arc1p-N adopts a fold similar to the C-terminal domain of glutathione S-transferase (GST-C).	Domain
B, D, F, H	PF21972	Nuclear-export cofactor Arc1p (Arc1p_N_like)	Nuclear-export cofactor Arc1p	This is the N-terminal domain of nuclear-export cofactor Arc1p (Arc1p-N). Arc1p-N and GluRS-N are known to be necessary and sufficient for formation of the yeast aaRS complex in vivo and in vitro. They are likely to form a stable complex with each ot ...	This is the N-terminal domain of nuclear-export cofactor Arc1p (Arc1p-N). Arc1p-N and GluRS-N are known to be necessary and sufficient for formation of the yeast aaRS complex in vivo and in vitro. They are likely to form a stable complex with each other. Arc1p-N adopts a fold similar to the C-terminal domain of glutathione S-transferase (GST-C).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Eukaryotic translation elongation factor 1 epsilon-1	-	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction DNA damage response, signal transduction by p53 class mediator intracellular signal transduction cell communication positive regulation of response to stimulus cellular response to stress regulation of intracellular signal transduction cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of cellular response to stress positive regulation of biological process regulation of signal transduction DNA damage response, signal transduction by p53 class mediator intracellular signal transduction cell communication positive regulation of response to stimulus cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus DNA damage response regulation of cell communication signal transduction in response to DNA damage cellular process positive regulation of signaling regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process regulation of cellular senescence cellular senescence positive regulation of metabolic process positive regulation of cellular senescence metabolic process regulation of metabolic process response to peptide response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor biosynthetic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex cytoplasm cytosol nucleoplasm
B, D, F, H	Glutamate--tRNA ligase	glutamate-tRNA ligase activity ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA catalytic activity ligase activity protein binding binding enzyme binding GTPase binding adenyl ribonucleotide binding nucleotide binding glutamate-tRNA ligase activity ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA catalytic activity ligase activity protein binding binding enzyme binding GTPase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein homodimerization activity protein dimerization activity RNA binding RNA stem-loop binding nucleic acid binding proline-tRNA ligase activity cation binding transition metal ion binding zinc ion binding metal ion binding	regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process import into cell regulation of localization transport regulation of lipid transport localization monocarboxylic acid transport fatty acid transport lipid import into cell long-chain fatty acid import into cell long-chain fatty acid transport organic anion transport carboxylic acid transport regulation of transport regulation of long-chain fatty acid import into cell lipid localization lipid transport establishment of localization regulation of fatty acid transport organic acid transport regulation of lipid localization macromolecule localization regulation of organic acid transport amino acid activation tRNA aminoacylation RNA metabolic process amino acid metabolic process tRNA aminoacylation for protein translation nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to type II interferon response to cytokine defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus response to peptide response to chemical immune system process defense response to other organism response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus glutamyl-tRNA aminoacylation prolyl-tRNA aminoacylation cellular response to nitrogen compound cellular response to stimulus response to endogenous stimulus response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to insulin cellular response to insulin stimulus cellular response to hormone stimulus	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex GAIT complex cell periphery plasma membrane catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR042450	Eukaryotic translation elongation factor 1 epsilon-1	Family
A, C, E, G	IPR010987	Glutathione S-transferase, C-terminal-like	Domain
A, C, E, G	IPR053836	Nuclear-export cofactor Arc1-like, N-terminal domain	Domain
A, C, E, G	IPR053837	AIMP3/p18, C-terminal domain	Domain
A, C, E, G	IPR036282	Glutathione S-transferase, C-terminal domain superfamily	Homologous Superfamily
B, D, F, H	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Homologous Superfamily
B, D, F, H	IPR009068	uS15/NS1, RNA-binding domain superfamily	Homologous Superfamily
B, D, F, H	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site	Conserved Site
B, D, F, H	IPR004154	Anticodon-binding	Domain
B, D, F, H	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
B, D, F, H	IPR053836	Nuclear-export cofactor Arc1-like, N-terminal domain	Domain
B, D, F, H	IPR006195	Aminoacyl-tRNA synthetase, class II	Domain
B, D, F, H	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	Domain
B, D, F, H	IPR036621	Anticodon-binding domain superfamily	Homologous Superfamily
B, D, F, H	IPR004499	Proline-tRNA ligase, class IIa, archaeal-type	Family
B, D, F, H	IPR000738	WHEP-TRS domain	Domain
B, D, F, H	IPR004526	Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic	Family
B, D, F, H	IPR000924	Glutamyl/glutaminyl-tRNA synthetase	Family
B, D, F, H	IPR020058	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	Domain
B, D, F, H	IPR017449	Prolyl-tRNA synthetase, class II	Homologous Superfamily
B, D, F, H	IPR020056	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal	Homologous Superfamily
B, D, F, H	IPR049437	tRNA synthetases class I (E and Q), anti-codon binding domain	Domain
B, D, F, H	IPR020059	Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain	Domain
B, D, F, H	IPR011035	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily	Homologous Superfamily
B, D, F, H	IPR033721	Prolyl-tRNA synthetase, catalytic domain	Domain
B, D, F, H	IPR036282	Glutathione S-transferase, C-terminal domain superfamily	Homologous Superfamily
B, D, F, H	IPR016061	Proline-tRNA ligase, class II, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: O43324	astrocytic tumor malignant colon neoplasm invasive ductal breast carcinoma ovarian cancer lung cancer Pick disease
B, D, F, H	Pharos: P07814	pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor Gaucher disease large cell medulloblastoma lung adenocarcinoma malignant glioma neurodegenerative disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis atypical teratoid rhabdoid tumor glioblastoma leukodystrophy lung cancer pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor Gaucher disease large cell medulloblastoma lung adenocarcinoma malignant glioma neurodegenerative disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis atypical teratoid rhabdoid tumor glioblastoma leukodystrophy lung cancer malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer plasma cell myeloma breast cancer invasive ductal breast carcinoma leukodystrophy, hypomyelinating, 15 malignant ependymoma medulloblastoma oligodendroglioma