Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth B]SCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
E [auth F]SCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyLDH/MDH/AglA-like 8059724 3000039 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]Ldh_1_C_9e4plyB2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
A [auth B]Ldh_1_Ne4plyB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
B [auth A]Ldh_1_C_9e4plyA2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
B [auth A]Ldh_1_Ne4plyA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
CLdh_1_C_9e4plyC2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
CLdh_1_Ne4plyC1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
E [auth F]Ldh_1_C_9e4plyF2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
E [auth F]Ldh_1_Ne4plyF1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
F [auth E]Ldh_1_C_9e4plyE2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
F [auth E]Ldh_1_Ne4plyE1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
GLdh_1_C_9e4plyG2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
GLdh_1_Ne4plyG1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
DLdh_1_C_9e4plyD2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
DLdh_1_Ne4plyD1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
HLdh_1_C_9e4plyH2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_9ECOD (1.6)
HLdh_1_Ne4plyH1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth B]3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
A [auth B]3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
B [auth A]3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
B [auth A]3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
C3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
C3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
E [auth F]3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
E [auth F]3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
F [auth E]3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
F [auth E]3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
G3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
G3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
D3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
D3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
H3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
H3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02866lactate/malate dehydrogenase, alpha/beta C-terminal domain (Ldh_1_C)lactate/malate dehydrogenase, alpha/beta C-terminal domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.
Domain
PF00056lactate/malate dehydrogenase, NAD binding domain (Ldh_1_N)lactate/malate dehydrogenase, NAD binding domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.
Domain