4L9P

Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4l9pa_	All alpha proteins	alpha-alpha superhelix	Protein prenylyltransferase	automated matches	automated matches	(Aspergillus fumigatus Af293 ) [TaxId: 330879 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Protein prenylyltransferase	8081648	4001331	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Protein prenylyltransferase	8081649	3001312	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PPTA	e4l9pA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PPTA	ECOD (1.6)
B	SQHop_cyclase_C	e4l9pB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: SQHop_cyclase_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.120	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Protein prenylyltransferase	CATH (4.3.0)
B	1.50.10.20	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01239	Protein prenyltransferase alpha subunit repeat (PPTA)	Protein prenyltransferase alpha subunit repeat	-	Repeat
B	PF00432	Prenyltransferase alpha-alpha toroid domain (Prenyltrans)	Prenyltransferase and squalene oxidase repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CaaX farnesyltransferase alpha subunit Ram2	protein farnesyltransferase activity catalytic activity, acting on a protein protein prenyltransferase activity prenyltransferase activity transferase activity catalytic activity transferase activity, transferring alkyl or aryl (other than methyl) groups CAAX-protein geranylgeranyltransferase activity protein geranylgeranyltransferase activity	protein farnesylation macromolecule modification protein prenylation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process prenylation protein modification process biosynthetic process gene expression macromolecule biosynthetic process peptide pheromone maturation protein farnesylation macromolecule modification protein prenylation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process prenylation protein modification process biosynthetic process gene expression macromolecule biosynthetic process peptide pheromone maturation protein maturation	protein-containing complex protein farnesyltransferase complex cellular anatomical structure intracellular anatomical structure catalytic complex polyprenyl diphosphate synthase complex cytoplasm transferase complex CAAX-protein geranylgeranyltransferase complex intracellular protein-containing complex
B	CaaX farnesyltransferase beta subunit Ram1	isomerase activity catalytic activity protein farnesyltransferase activity catalytic activity, acting on a protein protein prenyltransferase activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding isomerase activity catalytic activity protein farnesyltransferase activity catalytic activity, acting on a protein protein prenyltransferase activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	protein farnesylation macromolecule modification protein prenylation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process prenylation protein modification process	protein-containing complex protein farnesyltransferase complex cellular anatomical structure intracellular anatomical structure catalytic complex polyprenyl diphosphate synthase complex cytoplasm transferase complex
C	LYS-CYS-VAL-VAL-MET (CAAX peptide)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002088	Protein prenyltransferase, alpha subunit	Repeat
B	IPR045089	Prenyltransferase subunit beta	Family
B	IPR026872	Protein farnesyltransferase subunit beta	Family
B	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
B	IPR001330	Prenyltransferase alpha-alpha toroid domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.