4L0N | pdb_00004l0n

Crystal structure of STK3 (MST2) SARAH domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Mst1_SARAH	e4l0nA1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
B	Mst1_SARAH	e4l0nB1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
C	Mst1_SARAH	e4l0nC1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
D	Mst1_SARAH	e4l0nD1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
E	Mst1_SARAH	e4l0nE1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
F	Mst1_SARAH	e4l0nF1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
G	Mst1_SARAH	e4l0nG1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
H	Mst1_SARAH	e4l0nH1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
I	Mst1_SARAH	e4l0nI1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)
J	Mst1_SARAH	e4l0nJ1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: Mst1_SARAH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
B	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
C	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
D	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
E	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
F	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
G	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
H	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
I	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)
J	4.10.170.10	Few Secondary Structures	Irregular	p53, subunit A	p53-like tetramerisation domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF11629	C terminal SARAH domain of Mst1 (Mst1_SARAH)	C terminal SARAH domain of Mst1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Serine/threonine-protein kinase 3	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity kinase regulator activity histone H2BS14 kinase activity histone H2B kinase activity identical protein binding protein binding histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity transcription regulator activity transcription regulator activator activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity cation binding magnesium ion binding metal ion binding histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular response to stimulus regulation of biological process regulation of cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication cellular process signal transduction Wnt signaling pathway cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular component organization or biogenesis apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process cellular developmental process primitive hemopoiesis hemopoiesis animal organ development cell development embryo development embryonic hemopoiesis cell differentiation embryonic organ development protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport embryonic epithelial tube formation chordate embryonic development tube formation epithelial tube formation tube morphogenesis embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway apoptotic signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of JNK cascade JNK cascade positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction positive regulation of signaling protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process fat cell differentiation positive regulation of fat cell differentiation regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation phosphatidylinositol 3-kinase/protein kinase B signal transduction protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to centrosome regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction hippo signaling positive regulation of hippo signaling regulation of hippo signaling heart development endocardium development circulatory system development positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic signaling pathway hepatocyte apoptotic process epithelial cell apoptotic process cell differentiation involved in embryonic placenta development placenta development reproductive process developmental process involved in reproduction in utero embryonic development embryonic placenta development regulation of cell differentiation involved in embryonic placenta development regulation of reproductive process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle centrosome microtubule organizing center cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton protein-containing complex membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle centrosome microtubule organizing center cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton protein-containing complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000719	Protein kinase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR011524	SARAH domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR024205	Mst1/2 SARAH domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR049568	Mst2, SARAH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Pharos: Q13188	Crohn disease malignant mesothelioma ovarian cancer pituitary cancer exocrine pancreatic carcinoma malignant pancreatic neoplasm Ovarian clear cell carcinoma psoriasis glioblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.