4JLQ | pdb_00004jlq

Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IBN_N	e4jlqA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
A	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
A	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transportin-1	small GTPase binding protein binding binding enzyme binding GTPase binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity RNA binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus cellular process intracellular protein transport	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle
B	Nuclear polyadenylated RNA-binding protein NAB2	RNA binding binding nucleic acid binding mRNA binding ribonuclease P RNA binding rRNA binding 5S rRNA binding 7S RNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding cation binding transition metal ion binding zinc ion binding RNA binding binding nucleic acid binding mRNA binding ribonuclease P RNA binding rRNA binding 5S rRNA binding 7S RNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding tRNA binding	regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization negative regulation of mRNA metabolic process regulation of mRNA catabolic process positive regulation of biosynthetic process negative regulation of cellular process regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of catabolic process RNA destabilization nuclear-transcribed mRNA catabolic process biological regulation negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of mRNA stability positive regulation of catabolic process negative regulation of biosynthetic process positive regulation of gene expression positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase III RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase III regulation of RNA biosynthetic process regulation of transcription by RNA polymerase III nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040122	Importin beta family	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR001494	Importin-beta, N-terminal domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR000357	HEAT repeat	Repeat
B	IPR049017	Nab2, type CCCH zinc finger 4	Domain
B	IPR048410	RNA-binding, Nab2-type zinc finger	Domain
B	IPR041044	Nuclear polyadenylated RNA-binding 2 protein, CCCH zinc finger 1	Domain
B	IPR040366	Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14	Family
B	IPR021083	Nuclear abundant poly(A) RNA-binding protein Nab2, N-terminal	Domain
B	IPR043094	Nab2/ZC3H14, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92973	malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma acne psoriasis atopic eczema subependymal giant cell astrocytoma chronic obstructive pulmonary disease esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma acne psoriasis atopic eczema subependymal giant cell astrocytoma chronic obstructive pulmonary disease esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma Alzheimer disease rheumatoid arthritis atrial fibrillation tuberculosis Crohn disease exocrine pancreatic carcinoma invasive ductal breast carcinoma lung cancer malignant glioma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease primitive neuroectodermal tumor astrocytic tumor Sjogren syndrome atypical teratoid rhabdoid tumor ulcerative colitis dermatomyositis glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.