4C0Z

The N-terminal domain of the Streptococcus pyogenes pilus tip adhesin Cpa

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	TED_1st	e4c0zB1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
B	TED_2nd	e4c0zB2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
D	TED_1st	e4c0zD1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
D	TED_2nd	e4c0zD2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
E	TED_1st	e4c0zE1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
E	TED_2nd	e4c0zE2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
H	TED_1st	e4c0zH1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
H	TED_2nd	e4c0zH2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
I	TED_1st	e4c0zI1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
I	TED_2nd	e4c0zI2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
J	TED_1st	e4c0zJ1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
J	TED_2nd	e4c0zJ2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
K	TED_1st	e4c0zK1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
K	TED_2nd	e4c0zK2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
A	TED_1st	e4c0zA1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
A	TED_2nd	e4c0zA2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
C	TED_1st	e4c0zC1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
C	TED_2nd	e4c0zC2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
F	TED_1st	e4c0zF1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
F	TED_2nd	e4c0zF2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
G	TED_1st	e4c0zG1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
G	TED_2nd	e4c0zG2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)
L	TED_1st	e4c0zL1	A: beta barrels	X: OB-fold	H: Pilus-presented adhesin barrel insertion domain (From Topology)	T: Pilus-presented adhesin barrel insertion domain	F: TED_1st	ECOD (1.6)
L	TED_2nd	e4c0zL2	A: alpha arrays	X: Pilus-presented adhesin helical insertion domain (From Topology)	H: Pilus-presented adhesin helical insertion domain (From Topology)	T: Pilus-presented adhesin helical insertion domain	F: TED_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
B	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
D	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
E	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
E	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
H	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
H	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
I	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
I	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
J	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
J	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
K	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
K	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
A	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
A	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
C	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
C	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
F	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
F	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
G	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
G	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
L	2.30.30.670	Mainly Beta	Roll	SH3 type barrels.	Thioester domain	CATH (4.3.0)
L	1.10.150.480	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF08341	Thioester domain (TED)	Thioester domain	This domain is found near the N-terminus of a variety of bacterial surface proteins and pili. This domain contains an unusual covalent ester bond between a conserved cysteine and glutamine residue [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	ANCILLARY PROTEIN 2	-	-	pilus cell projection cellular anatomical structure

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR053671	Pilus tip thioester-containing adhesin	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR046022	Domain of unknown function DUF5979	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR041033	SpaA-like, prealbumin fold domain subgroup 1	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR023849	TQXA domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013552	Thioester domain	Domain