The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively [1]. The transglycosylase domain catalyses the polymerisation of murein glycan chains ([4]).
Bacterial peptidoglycan glycosyltransferases (PGT) catalyse the polymerization of peptidoglycan (lipid II) into linear glycan chains, which is an essential part of peptidoglycan biosynthesis. It uses lipid II precursors to synthesize glycan chains of the peptidoglycan, the polymeric layer in the cell wall of bacteria. PGT inhibition leads to bacterial cell wall lysis, making it an important topic of research.
Defined by 4 residues: GLU:A-94 [auth A-100]GLY:A-125 [auth A-131]SER:A-126 [auth A-132]GLN:A-130 [auth A-136]