Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth B]SCOP2B SuperfamilyAcid proteases 8042430 3001059 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyAcid proteases 8042430 3001059 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyAcid proteases 8042430 3001059 SCOP2B (2022-06-29)
C [auth D]SCOP2B SuperfamilyAcid proteases 8042430 3001059 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]RVPe3oxwB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)
B [auth A]RVPe3oxwA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)
D [auth C]RVPe3oxwC1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)
C [auth D]RVPe3oxwD1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth B]2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)
B [auth A]2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)
D [auth C]2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)
C [auth D]2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
B [auth A],
C [auth D],
D [auth C]
PF00077Retroviral aspartyl protease (RVP)Retroviral aspartyl proteaseSingle domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ...Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam:PF00026).
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
B [auth A],
C [auth D],
D [auth C]
HIV-1 Protease

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR036397Ribonuclease H superfamilyHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR001995Peptidase A2A, retrovirus, catalyticDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR001878Zinc finger, CCHC-typeDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR018061RetropepsinsDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR010661Reverse transcriptase thumbDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR002156Ribonuclease H domainDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR003308Integrase, N-terminal zinc-binding domainDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR001584Integrase, catalytic coreDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR010999Retroviral matrix proteinHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR001969Aspartic peptidase, active siteActive Site
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR017856Integrase-like, N-terminalHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR001037Integrase, C-terminal, retroviralDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR034170Retropepsin-like catalytic domainDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR000477Reverse transcriptase domainDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR010659Reverse transcriptase connectionDomain
A [auth B],
B [auth A],
C [auth D],
D [auth C]
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily