3OXW
Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | d3oxwb_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | Human immunodeficiency virus type 1 protease | HIV-1 (HIV-1 M:B_ARV2/SF2 ) [TaxId: 11685 ], | SCOPe (2.08) |
B [auth A] | d3oxwa_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | Human immunodeficiency virus type 1 protease | HIV-1 (HIV-1 M:B_ARV2/SF2 ) [TaxId: 11685 ], | SCOPe (2.08) |
D [auth C] | d3oxwc_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | Human immunodeficiency virus type 1 protease | HIV-1 (HIV-1 M:B_ARV2/SF2 ) [TaxId: 11685 ], | SCOPe (2.08) |
C [auth D] | d3oxwd_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | Human immunodeficiency virus type 1 protease | HIV-1 (HIV-1 M:B_ARV2/SF2 ) [TaxId: 11685 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth B] | SCOP2B Superfamily | Acid proteases | 8042430 | 3001059 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | Acid proteases | 8042430 | 3001059 | SCOP2B (2022-06-29) |
D [auth C] | SCOP2B Superfamily | Acid proteases | 8042430 | 3001059 | SCOP2B (2022-06-29) |
C [auth D] | SCOP2B Superfamily | Acid proteases | 8042430 | 3001059 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | RVP | e3oxwB1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
B [auth A] | RVP | e3oxwA1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
D [auth C] | RVP | e3oxwC1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
C [auth D] | RVP | e3oxwD1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth B] | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
B [auth A] | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
D [auth C] | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
C [auth D] | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], B [auth A], C [auth D], D [auth C] | PF00077 | Retroviral aspartyl protease (RVP) | Retroviral aspartyl protease | Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ... | Domain |