3NRX | pdb_00003nrx

Insights into anti-parallel microtubule crosslinking by PRC1, a conserved non-motor microtubule binding protein

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MAP65_ASE1_2nd	e3nrxA1	A: alpha bundles	X: Spectrin repeat-like	H: Spectrin repeat (From Topology)	T: Spectrin repeat	F: MAP65_ASE1_2nd	ECOD (1.6)
B	MAP65_ASE1_2nd	e3nrxB1	A: alpha bundles	X: Spectrin repeat-like	H: Spectrin repeat (From Topology)	T: Spectrin repeat	F: MAP65_ASE1_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.1520	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.1520	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein regulator of cytokinesis 1	cytoskeletal protein binding protein binding binding kinesin binding microtubule binding tubulin binding kinase binding enzyme binding protein kinase binding identical protein binding	mitotic spindle elongation spindle midzone assembly spindle elongation microtubule cytoskeleton organization membraneless organelle assembly mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis mitotic spindle elongation spindle midzone assembly spindle elongation microtubule cytoskeleton organization membraneless organelle assembly mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation cellular process microtubule-based process mitotic spindle midzone assembly cytoskeleton organization cell division regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division regulation of cell cycle	midbody cellular anatomical structure intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cytoplasm cytosol cell periphery midbody cellular anatomical structure intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intercellular bridge chromosome mitotic spindle mitotic spindle midzone spindle midzone polymeric cytoskeletal fiber spindle microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex contractile ring

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007145	Microtubule-associated protein, MAP65/Ase1/PRC1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O43663	breast carcinoma IgA glomerulonephritis breast cancer large cell medulloblastoma malignant colon neoplasm Malignant neoplasm of breast adrenal cortex carcinoma myocardial infarction atypical teratoid rhabdoid tumor ovarian cancer bipolar disorder pituitary cancer cancer Sjogren syndrome endometriosis breast carcinoma IgA glomerulonephritis breast cancer large cell medulloblastoma malignant colon neoplasm Malignant neoplasm of breast adrenal cortex carcinoma myocardial infarction atypical teratoid rhabdoid tumor ovarian cancer bipolar disorder pituitary cancer cancer Sjogren syndrome endometriosis ulcerative colitis hepatocellular carcinoma interstitial cystitis lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm maturity-onset diabetes of the young atopic eczema nasopharyngeal carcinoma autism spectrum disorder pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor ductal breast carcinoma in situ subependymal giant cell astrocytoma glioblastoma hypertensive disorder invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma attention deficit hyperactivity disorder, inattentive type non-small cell lung carcinoma B-cell chronic lymphocytic leukemia pancreatic intraductal papillary-mucinous neoplasm psoriasis endogenous depression type 2 diabetes mellitus heart disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.