3NQZ | pdb_00003nqz

Crystal structure of the autoprocessed Vibriolysin MCP-02 with E369A mutation

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	FTP-like	8049613	4006558	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FTP/YycH/YycI-like	8092132	3002371	SCOP2 (2022-06-29)
B	SCOP2 Family	Thermolysin-like	8092133	4001610	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Metalloproteases (zincins), catalytic domain	8092134	3001975	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FTP	e3nqzA1	A: a+b two layers	X: Cystatin-like	H: Cystatin/monellin (From Topology)	T: Cystatin/monellin	F: FTP	ECOD (1.6)
A	PepSY	e3nqzA2	A: a+b two layers	X: Cystatin-like	H: Cystatin/monellin (From Topology)	T: Cystatin/monellin	F: PepSY	ECOD (1.6)
B	Peptidase_M4_C	e3nqzB1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M4_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.490	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.10.450.40	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.170.10	Alpha Beta	Roll	Elastase	domain 1	CATH (4.3.0)
B	1.10.390.10	Mainly Alpha	Orthogonal Bundle	Neutral Protease	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03413	Peptidase propeptide and YPEB domain (PepSY)	Peptidase propeptide and YPEB domain	This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase & Bacillus subtilis ...	This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase & Bacillus subtilis YPEB.	Domain
A	PF07504	Fungalysin/Thermolysin Propeptide Motif (FTP)	Fungalysin/Thermolysin Propeptide Motif	-	Motif
B	PF01447	Thermolysin metallopeptidase, catalytic domain (Peptidase_M4)	Thermolysin metallopeptidase, catalytic domain		Domain
B	PF02868	Thermolysin metallopeptidase, alpha-helical domain (Peptidase_M4_C)	Thermolysin metallopeptidase, alpha-helical domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Secreted metalloprotease Mcp02	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	-
B	Secreted metalloprotease Mcp02	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001570	Peptidase M4, C-terminal	Domain
A	IPR013856	Peptidase M4 domain	Domain
A	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
A	IPR050728	Extracellular Zinc Metalloprotease M4	Family
A	IPR011096	FTP domain	Domain
A	IPR025711	PepSY domain	Domain
A	IPR007280	Peptidase, C-terminal, archaeal/bacterial	Domain
A	IPR023612	Peptidase M4	Family
B	IPR001570	Peptidase M4, C-terminal	Domain
B	IPR013856	Peptidase M4 domain	Domain
B	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
B	IPR050728	Extracellular Zinc Metalloprotease M4	Family
B	IPR011096	FTP domain	Domain
B	IPR025711	PepSY domain	Domain
B	IPR007280	Peptidase, C-terminal, archaeal/bacterial	Domain
B	IPR023612	Peptidase M4	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.