3N8W

Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3n8wa2	All alpha proteins	Heme-dependent peroxidases	Heme-dependent peroxidases	Myeloperoxidase-like	Prostaglandin H2 synthase	sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
A	d3n8wa1	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	Prostaglandin H2 synthase-1, EGF-like module	sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	EGF/Laminin-like	8039679	3000412	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Heme-dependent peroxidases	8039678	3000844	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Heme-dependent peroxidases	8039678	3000844	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EGF/Laminin-like	8039679	3000412	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	An_peroxidase	e3n8wB1	A: alpha complex topology	X: Heme-dependent peroxidases (From Topology)	H: Heme-dependent peroxidases (From Topology)	T: Heme-dependent peroxidases	F: An_peroxidase	ECOD (1.6)
B	hEGF_4	e3n8wB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: hEGF_4	ECOD (1.6)
A	An_peroxidase	e3n8wA1	A: alpha complex topology	X: Heme-dependent peroxidases (From Topology)	H: Heme-dependent peroxidases (From Topology)	T: Heme-dependent peroxidases	F: An_peroxidase	ECOD (1.6)
A	hEGF_4	e3n8wA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: hEGF_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
B	1.10.640.10	Mainly Alpha	Orthogonal Bundle	Myeloperoxidase, subunit C	Haem peroxidase domain superfamily, animal type	CATH (4.3.0)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
A	1.10.640.10	Mainly Alpha	Orthogonal Bundle	Myeloperoxidase, subunit C	Haem peroxidase domain superfamily, animal type	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF03098	Animal haem peroxidase (An_peroxidase)	Animal haem peroxidase	-	Domain
A	PF03098	Animal haem peroxidase (An_peroxidase)	Animal haem peroxidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Prostaglandin G/H synthase 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen identical protein binding protein binding binding protein homodimerization activity protein dimerization activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen prostaglandin-endoperoxide synthase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on single donors with incorporation of molecular oxygen dioxygenase activity cation binding ion binding metal ion binding small molecule binding	multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process prostanoid metabolic process icosanoid biosynthetic process small molecule metabolic process prostaglandin biosynthetic process prostanoid biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process arachidonate metabolic process long-chain fatty acid metabolic process cyclooxygenase pathway olefinic compound metabolic process response to oxidative stress response to stimulus response to stress	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cell projection neuron projection plasma membrane bounded cell projection
A	Prostaglandin G/H synthase 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen identical protein binding protein binding binding protein homodimerization activity protein dimerization activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen prostaglandin-endoperoxide synthase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on single donors with incorporation of molecular oxygen dioxygenase activity cation binding ion binding metal ion binding small molecule binding	multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process prostanoid metabolic process icosanoid biosynthetic process small molecule metabolic process prostaglandin biosynthetic process prostanoid biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process arachidonate metabolic process long-chain fatty acid metabolic process cyclooxygenase pathway olefinic compound metabolic process response to oxidative stress response to stimulus response to stress	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR019791	Haem peroxidase, animal-type	Family
B	IPR050783	Oxylipin biosynthesis and metabolism	Family
B	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
B	IPR010255	Haem peroxidase superfamily	Homologous Superfamily
B	IPR000742	EGF-like domain	Domain
A	IPR019791	Haem peroxidase, animal-type	Family
A	IPR050783	Oxylipin biosynthesis and metabolism	Family
A	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
A	IPR010255	Haem peroxidase superfamily	Homologous Superfamily
A	IPR000742	EGF-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.