3N5A

Synaptotagmin-7, C2B-domain, calcium bound

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3n5aa_	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	automated matches	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Synaptotagmin-like (S variant)	8078508	4002234	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8078509	3000965	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C2_2	e3n5aA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00168	C2 domain (C2)	C2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Synaptotagmin-7	binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding calcium-dependent phospholipid binding protein binding SNARE binding calmodulin binding binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding calcium-dependent phospholipid binding protein binding SNARE binding calmodulin binding cation binding metal ion binding modified amino acid binding phosphatidylserine binding	import into cell transport membrane fusion organelle membrane fusion vesicle-mediated transport vesicle organization cellular component organization cellular component biogenesis localization lysosome organization cellular component assembly phagolysosome assembly phagocytosis cellular component organization or biogenesis import into cell transport membrane fusion organelle membrane fusion vesicle-mediated transport vesicle organization cellular component organization cellular component biogenesis localization lysosome organization cellular component assembly phagolysosome assembly phagocytosis cellular component organization or biogenesis membrane organization vacuole organization organelle assembly lytic vacuole organization phagosome-lysosome fusion phagosome maturation establishment of localization organelle fusion organelle organization cellular process endocytosis vesicle fusion regulation of localization regulated exocytosis regulation of biological process regulation of cellular process regulation of calcium ion-dependent exocytosis secretion regulation of transport biological regulation export from cell regulation of vesicle-mediated transport regulation of secretion regulation of regulated secretory pathway secretion by cell regulation of secretion by cell exocytosis regulation of exocytosis calcium-ion regulated exocytosis synaptic vesicle recycling cellular localization establishment of localization in cell synaptic vesicle cycle vesicle-mediated transport in synapse monoamine transport nitrogen compound transport signaling regulation of catecholamine secretion organic hydroxy compound transport dopamine transport cell communication catecholamine transport signal release cell-cell signaling dopamine secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion regulation of cellular component organization regulation of phagocytosis regulation of endocytosis protein localization establishment of protein localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of hormone secretion regulation of protein localization regulation of peptide secretion hormone secretion protein localization to extracellular region peptide secretion amide transport regulation of signaling regulation of peptide transport regulation of establishment of protein localization regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion calcium ion regulated lysosome exocytosis synaptic vesicle exocytosis synaptic signaling calcium ion-regulated exocytosis of neurotransmitter trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse anterograde trans-synaptic signaling positive regulation of organelle organization positive regulation of synaptic vesicle fusion to presynaptic active zone membrane regulation of synaptic vesicle membrane organization endomembrane system organization vesicle fusion to plasma membrane positive regulation of synaptic vesicle membrane organization regulation of organelle organization positive regulation of vesicle fusion positive regulation of cellular component organization positive regulation of biological process calcium-dependent activation of synaptic vesicle fusion regulation of vesicle fusion positive regulation of cellular process regulation of synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle fusion to presynaptic active zone membrane positive regulation of transport synaptic vesicle membrane organization exocytic process regulation of synaptic plasticity modulation of chemical synaptic transmission short-term synaptic potentiation regulation of trans-synaptic signaling intracellular lipid transport intracellular cholesterol transport vesicle-mediated cholesterol transport lipid localization intracellular transport lipid transport intracellular sterol transport cytosolic transport cholesterol transport sterol transport wound healing response to stimulus plasma membrane repair response to stress plasma membrane organization response to wounding multicellular organismal process tissue remodeling regulation of bone remodeling bone remodeling regulation of multicellular organismal process regulation of tissue remodeling glucagon secretion regulation of glucagon secretion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery presynapse synapse cell junction membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane somatodendritic compartment cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery presynapse synapse cell junction membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle early phagosome intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle endocytic vesicle lytic vacuole vacuole lysosome GABA-ergic synapse glutamatergic synapse phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane endocytic vesicle membrane organelle membrane vacuolar membrane lytic vacuole membrane lysosomal membrane peroxisome microbody microbody membrane peroxisomal membrane cell body neuronal cell body transport vesicle membrane endomembrane system synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane secretory vesicle exocytic vesicle axon axon terminus distal axon neuron projection terminus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000008	C2 domain	Domain
A	IPR001565	Synaptotagmin	Domain
A	IPR037732	Synaptotagmin 7, C2A domain	Domain
A	IPR037741	Synaptotagmin 7, C2B domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM				C2 domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.