3N1S

Crystal structure of wild type ecHint GMP complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3n1sa_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C [auth E]	d3n1se_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G [auth M]	d3n1sm_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H [auth N]	d3n1sn_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d3n1sb_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D [auth F]	d3n1sf_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E [auth I]	d3n1si_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth J]	d3n1sj_	Alpha and beta proteins (a+b)	HIT-like	HIT-like	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HIT	e3n1sA1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
C [auth E]	HIT	e3n1sE1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
G [auth M]	HIT	e3n1sM1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
H [auth N]	HIT	e3n1sN1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
B	HIT	e3n1sB1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
D [auth F]	HIT	e3n1sF1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
E [auth I]	HIT	e3n1sI1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
F [auth J]	HIT	e3n1sJ1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
C [auth E]	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
G [auth M]	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
H [auth N]	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
B	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
D [auth F]	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
E [auth I]	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
F [auth J]	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth E], D [auth F], E [auth I], A, B, C [auth E], D [auth F], E [auth I], F [auth J], G [auth M], H [auth N]	PF01230	HIT domain (HIT)	HIT domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth E], D [auth F], E [auth I], A, B, C [auth E], D [auth F], E [auth I], F [auth J], G [auth M], H [auth N]	HIT-like protein hinT	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides adenosine 5'-monophosphoramidase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds identical protein binding protein binding binding protein homodimerization activity protein dimerization activity nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides adenosine 5'-monophosphoramidase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds identical protein binding protein binding binding protein homodimerization activity protein dimerization activity nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	catabolic process oxoacid metabolic process alanine catabolic process D-alanine catabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process D-alanine metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process carboxylic acid catabolic process D-amino acid metabolic process small molecule metabolic process catabolic process oxoacid metabolic process alanine catabolic process D-alanine catabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process D-alanine metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process carboxylic acid catabolic process D-amino acid metabolic process small molecule metabolic process amino acid catabolic process non-proteinogenic amino acid catabolic process carboxylic acid metabolic process primary metabolic process alpha-amino acid catabolic process metabolic process cellular process small molecule catabolic process alanine metabolic process D-amino acid catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth E], D [auth F], E [auth I], A, B, C [auth E], D [auth F], E [auth I], F [auth J], G [auth M], H [auth N]	IPR036265	HIT-like superfamily	Homologous Superfamily
A, B, C [auth E], D [auth F], E [auth I], A, B, C [auth E], D [auth F], E [auth I], F [auth J], G [auth M], H [auth N]	IPR001310	Histidine triad (HIT) protein	Family
A, B, C [auth E], D [auth F], E [auth I], A, B, C [auth E], D [auth F], E [auth I], F [auth J], G [auth M], H [auth N]	IPR011146	HIT-like domain	Domain
A, B, C [auth E], D [auth F], E [auth I], A, B, C [auth E], D [auth F], E [auth I], F [auth J], G [auth M], H [auth N]	IPR019808	Histidine triad, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.