3MJ7 | pdb_00003mj7

Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set_9	e3mj7A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_9	ECOD (1.6)
B	I-set_2	e3mj7B6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_2	ECOD (1.6)
B	I-set_7	e3mj7B5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	AMICA1 (Junctional adhesion molecule-like)	2V-LIKE	Mus musculus (house mouse)	AMICA1*01	V-LIKE-DOMAIN V-LIKE	RPI	2V-LIKE	IMGT (202510-0)
B	mCAR (Coxsackievirus and adenovirus receptor homolog)	1V-1C-LIKE	Mus musculus (house mouse)	CXADR*01	V-LIKE-DOMAIN V-LIKE, C-LIKE-DOMAIN C-LIKE	RPI	1V-1C-LIKE	IMGT (202510-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
B	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Junctional adhesion molecule-like	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	wound healing regulation of biological process cell population proliferation regulation of cellular process response to stimulus positive regulation of cell population proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process response to stress regulation of cell population proliferation cellular process regulation of epithelial cell proliferation response to wounding wound healing regulation of biological process cell population proliferation regulation of cellular process response to stimulus positive regulation of cell population proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process response to stress regulation of cell population proliferation cellular process regulation of epithelial cell proliferation response to wounding epithelial cell proliferation positive regulation of cellular process positive regulation of epithelial cell proliferation involved in wound healing multicellular organismal process gamma-delta T cell activation T cell activation immune system process cell activation lymphocyte activation leukocyte activation leukocyte migration mononuclear cell migration cellular extravasation myeloid leukocyte migration cell migration cell motility monocyte extravasation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules	cell-cell junction apical junction complex bicellular tight junction cellular anatomical structure tight junction anchoring junction cell junction cell periphery plasma membrane membrane
B	Coxsackievirus and adenovirus receptor homolog	cell adhesion molecule binding protein binding binding cell adhesion mediator activity cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell-cell adhesion mediator activity protein binding involved in heterotypic cell-cell adhesion PDZ domain binding protein domain specific binding beta-catenin binding connexin binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development wound healing regulation of biological process cell population proliferation regulation of cellular process response to stimulus positive regulation of cell population proliferation developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development wound healing regulation of biological process cell population proliferation regulation of cellular process response to stimulus positive regulation of cell population proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process response to stress regulation of cell population proliferation cellular process regulation of epithelial cell proliferation response to wounding epithelial cell proliferation positive regulation of cellular process positive regulation of epithelial cell proliferation involved in wound healing heart process system process regulation of heart contraction regulation of system process cell communication circulatory system process regulation of blood circulation AV node cell to bundle of His cell communication cardiac conduction regulation of multicellular organismal process cell communication involved in cardiac conduction heart contraction blood circulation heart growth developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth organ growth tissue development striated muscle tissue development muscle cell proliferation cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation gamma-delta T cell activation T cell activation immune system process cell activation lymphocyte activation leukocyte activation cell chemotaxis cellular response to stimulus chemotaxis neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion regulation of AV node cell action potential AV node cell action potential signaling cell-cell signaling involved in cardiac conduction regulation of cardiac muscle cell action potential regulation of biological quality regulation of action potential AV node cell to bundle of His cell signaling cell-cell signaling action potential regulation of cell communication cardiac muscle cell action potential regulation of membrane potential regulation of growth regulation of cardiac muscle tissue growth regulation of developmental process negative regulation of biological process negative regulation of cardiac muscle tissue growth negative regulation of organ growth negative regulation of growth regulation of organ growth regulation of heart growth negative regulation of cellular process regulation of cardiac muscle cell proliferation negative regulation of cell population proliferation regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth negative regulation of developmental process negative regulation of developmental growth negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization regulation of localization import into cell cellular localization regulation of cellular component organization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell regulation of endocytosis synaptic vesicle endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization endocytosis homotypic cell-cell adhesion heterotypic cell-cell adhesion AV node cell-bundle of His cell adhesion involved in cell communication cardiac muscle cell-cardiac muscle cell adhesion sexual reproduction reproductive process multicellular organismal reproductive process germ cell migration gamete generation cardiac muscle cell development cellular developmental process cell development muscle cell differentiation muscle structure development striated muscle cell development muscle cell development cell differentiation cardiac cell development cardiac muscle cell differentiation cardiocyte differentiation striated muscle cell differentiation mitochondrion organization multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process anatomical structure homeostasis tissue homeostasis cell junction organization cell-cell junction organization	cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery presynapse synapse membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane basal part of cell basal plasma membrane cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery presynapse synapse membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane basal part of cell basal plasma membrane basolateral plasma membrane intracellular anatomical structure cytoplasm glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection adherens junction cell body intercalated disc cell-cell contact zone actin-based cell projection filopodium acrosomal vesicle membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle vesicle membrane microdomain membrane raft growth cone axon distal axon site of polarized growth apicolateral plasma membrane GABA-ergic synapse extracellular region apical junction complex bicellular tight junction tight junction nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR000920	Myelin P0 protein-related	Family
A	IPR013106	Immunoglobulin V-set domain	Domain
A	IPR003599	Immunoglobulin domain subtype	Domain
A	IPR007110	Immunoglobulin-like domain	Domain
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR013106	Immunoglobulin V-set domain	Domain
B	IPR003599	Immunoglobulin domain subtype	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR052307	Epithelial Junction Adhesion Regulator	Family
B	IPR003598	Immunoglobulin subtype 2	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.