Annotations: 3MDR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	p450	e3mdrB1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
A	p450	e3mdrA1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)
A	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cholesterol 24-hydroxylase	testosterone 16-beta-hydroxylase activity monooxygenase activity oxidoreductase activity catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding testosterone 16-beta-hydroxylase activity monooxygenase activity oxidoreductase activity catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen cholesterol 24-hydroxylase activity steroid hydroxylase activity	bile acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process organic hydroxy compound metabolic process steroid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process bile acid metabolic process biosynthetic process organic hydroxy compound biosynthetic process bile acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process organic hydroxy compound metabolic process steroid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process bile acid metabolic process biosynthetic process organic hydroxy compound biosynthetic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process steroid biosynthetic process lipid metabolic process sterol catabolic process alcohol catabolic process catabolic process lipid catabolic process sterol metabolic process cholesterol metabolic process alcohol metabolic process cholesterol catabolic process secondary alcohol metabolic process steroid catabolic process organic hydroxy compound catabolic process small molecule catabolic process cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus ketone metabolic process regulation of hormone levels biological regulation C21-steroid hormone metabolic process hormone metabolic process progesterone metabolic process olefinic compound metabolic process regulation of biological quality positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process cell communication long-term synaptic potentiation synaptic signaling positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication positive regulation of signaling developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development protein localization to membrane raft protein localization localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane	presynapse cellular anatomical structure synapse cell junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection postsynapse membrane-bounded organelle intracellular organelle intracellular anatomical structure presynapse cellular anatomical structure synapse cell junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection postsynapse membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002401	Cytochrome P450, E-class, group I	Family
A, B	IPR017972	Cytochrome P450, conserved site	Conserved Site
A, B	IPR001128	Cytochrome P450	Family
A, B	IPR039983	Cholesterol 24-hydroxylase	Family
A, B	IPR036396	Cytochrome P450 superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y6A2	Alzheimer disease malignant glioma oligodendroglioma Pick disease primitive neuroectodermal tumor Acute Confusional Senile Dementia atypical teratoid rhabdoid tumor esophageal candidiasis heart disease large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma HIV infectious disease malignant ependymoma Alzheimer disease malignant glioma oligodendroglioma Pick disease primitive neuroectodermal tumor Acute Confusional Senile Dementia atypical teratoid rhabdoid tumor esophageal candidiasis heart disease large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma HIV infectious disease malignant ependymoma myocardial infarction pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor glioblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.