Annotations: 3JBT

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Cytochrome c	8036431	3000815	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	ANAPC4_WD40_10	e3jbtE7	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
E	ANAPC4_WD40_10	e3jbtE8	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
E	KOG4658_like	e3jbtE6	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
E	NB-ARC_2nd	e3jbtE5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
E	EUF08240	e3jbtE3	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
E	NB-ARC_1st	e3jbtE2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
G	ANAPC4_WD40_10	e3jbtG6	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
G	ANAPC4_WD40_10	e3jbtG7	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
G	KOG4658_like	e3jbtG5	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
G	NB-ARC_2nd	e3jbtG3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
G	EUF08240	e3jbtG2	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
G	NB-ARC_1st	e3jbtG4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
I	ANAPC4_WD40_10	e3jbtI7	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
I	ANAPC4_WD40_10	e3jbtI8	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
I	KOG4658_like	e3jbtI1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
I	NB-ARC_2nd	e3jbtI2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
I	EUF08240	e3jbtI5	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
I	NB-ARC_1st	e3jbtI6	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
A	ANAPC4_WD40_10	e3jbtA6	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
A	ANAPC4_WD40_10	e3jbtA7	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
A	KOG4658_like	e3jbtA5	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
A	NB-ARC_2nd	e3jbtA1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
A	EUF08240	e3jbtA2	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
A	NB-ARC_1st	e3jbtA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
C	ANAPC4_WD40_10	e3jbtC5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
C	ANAPC4_WD40_10	e3jbtC6	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
C	KOG4658_like	e3jbtC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
C	NB-ARC_2nd	e3jbtC3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
C	EUF08240	e3jbtC4	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
C	NB-ARC_1st	e3jbtC2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
K	ANAPC4_WD40_10	e3jbtK6	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
K	ANAPC4_WD40_10	e3jbtK7	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
K	KOG4658_like	e3jbtK2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
K	NB-ARC_2nd	e3jbtK5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
K	EUF08240	e3jbtK3	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
K	NB-ARC_1st	e3jbtK4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
M	ANAPC4_WD40_10	e3jbtM7	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
M	ANAPC4_WD40_10	e3jbtM8	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
M	KOG4658_like	e3jbtM3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG4658_like	ECOD (1.6)
M	NB-ARC_2nd	e3jbtM5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: NB-ARC_2nd	ECOD (1.6)
M	EUF08240	e3jbtM4	A: alpha superhelices	X: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	H: Apoptotic protease-activating factor 1 (Apaf-1) helical domain (From Topology)	T: Apoptotic protease-activating factor 1 (Apaf-1) helical domain	F: EUF08240	ECOD (1.6)
M	NB-ARC_1st	e3jbtM6	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: NB-ARC_1st	ECOD (1.6)
D	Cytochrom_C_1	e3jbtD1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
B	Cytochrom_C_1	e3jbtB1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
F	Cytochrom_C_1	e3jbtF1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
H	Cytochrom_C_1	e3jbtH1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
J	Cytochrom_C_1	e3jbtJ1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
L	Cytochrom_C_1	e3jbtL1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
N	Cytochrom_C_1	e3jbtN1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
E	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
E	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
G	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
G	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
G	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
G	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
I	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
I	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
I	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
I	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
I	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
A	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
C	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
C	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
K	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
K	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
K	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
K	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
K	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
M	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
M	1.10.8.430	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
M	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
M	1.25.40.370	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
M	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
B	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
F	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
H	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
J	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
L	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
N	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M	PF00931	NB-ARC domain (NB-ARC)	NB-ARC domain		Domain
A, C, E, G, I A, C, E, G, I, K, M	PF21296	Apoptotic protease-activating factor 1-like, winged-helix domain (APAF-1-like_WHD)	Apoptotic protease-activating factor 1-like, winged-helix domain	This domain is found in Apoptotic protease-activating factor 1 from Mus musculus (APAF-1), responsible to ignite the downstream cascade of caspases in the mitochondrial pathway of apoptosis. This entry represents the winged-helix domain (WHD) [1-5]. ...	This domain is found in Apoptotic protease-activating factor 1 from Mus musculus (APAF-1), responsible to ignite the downstream cascade of caspases in the mitochondrial pathway of apoptosis. This entry represents the winged-helix domain (WHD) [1-5].	Domain
A, C, E, G, I A, C, E, G, I, K, M	PF17908	APAF-1 helical domain (APAF1_C)	APAF-1 helical domain	This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.	Domain
A, C, E, G, I A, C, E, G, I, K, M	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
B, D, F, H, J B, D, F, H, J, L, N	PF00034	Cytochrome c (Cytochrom_C)	Cytochrome c	The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, Pfam:PF06181, has now been merged into this family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M	Apoptotic protease-activating factor 1	binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding protein binding heat shock protein binding adenyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding protein binding heat shock protein binding adenyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding carbohydrate derivative binding ribonucleotide binding ADP binding enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein molecular function activator activity cysteine-type endopeptidase activator activity involved in apoptotic process hydrolase activity peptidase activator activity enzyme activator activity molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process catalytic activity peptidase activator activity involved in apoptotic process identical protein binding	developmental process cellular developmental process cell differentiation cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway developmental process cellular developmental process cell differentiation cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cell communication positive regulation of response to stimulus signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process biological regulation cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway intracellular signal transduction intrinsic apoptotic signaling pathway cellular response to endogenous stimulus cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to endogenous stimulus response to growth factor multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure head development forebrain development animal organ development brain development central nervous system development catabolic process macromolecule catabolic process regulation of DNA catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process cellular component organization execution phase of apoptosis DNA catabolic process apoptotic nuclear changes cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process regulation of apoptotic DNA fragmentation cellular component disassembly primary metabolic process DNA metabolic process regulation of macromolecule metabolic process regulation of catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process apoptotic DNA fragmentation cellular component disassembly involved in execution phase of apoptosis nucleic acid catabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process response to G1 DNA damage checkpoint signaling response to mitotic cell cycle checkpoint signaling response to biotic stimulus cellular response to biotic stimulus response to DNA integrity checkpoint signaling response to DNA damage checkpoint signaling response to cell cycle checkpoint signaling neuron apoptotic process response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to stress response to endoplasmic reticulum stress response to nutrient levels response to chemical response to nutrient kidney development renal system development muscle cell apoptotic process striated muscle cell apoptotic process cardiac muscle cell apoptotic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane-enclosed lumen extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle protein-containing complex apoptosome vesicle lumen cytoplasmic vesicle lumen secretory granule lumen nucleus
B, D, F, H, J B, D, F, H, J, L, N	Cytochrome c	binding lipid binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport mitochondrial electron transport, ubiquinol to cytochrome c aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport mitochondrial electron transport, ubiquinol to cytochrome c cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell death cell communication apoptotic signaling pathway signal transduction apoptotic process programmed cell death cytochrome complex assembly protein-tetrapyrrole linkage protein-containing complex organization primary metabolic process cytochrome c-heme linkage cellular component organization cellular component biogenesis cellular component assembly macromolecule modification protein-heme linkage protein-containing complex assembly protein metabolic process macromolecule metabolic process cellular component organization or biogenesis protein modification process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle mitochondrial envelope protein-containing complex cytochrome complex catalytic complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M	IPR041452	APAF-1 helical domain	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR019775	WD40 repeat, conserved site	Conserved Site
A, C, E, G, I A, C, E, G, I, K, M	IPR037963	Apoptotic Protease-Activating Factor 1, CARD domain	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR002182	NB-ARC	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR011029	Death-like domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR042197	Apoptotic protease-activating factors, helical domain	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR048975	Apoptotic protease-activating factor 1, winged-helix domain	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR001680	WD40 repeat	Repeat
A, C, E, G, I A, C, E, G, I, K, M	IPR001315	CARD domain	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR020472	G-protein beta WD-40 repeat	Repeat
A, C, E, G, I A, C, E, G, I, K, M	IPR017251	Apoptotic protease-activating factor 1	Family
B, D, F, H, J B, D, F, H, J, L, N	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N	IPR009056	Cytochrome c-like domain	Domain
B, D, F, H, J B, D, F, H, J, L, N	IPR002327	Cytochrome c, class IA/ IB	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G, I A, C, E, G, I, K, M	Pharos: O14727	transitional cell carcinoma renal cell carcinoma retinal detachment Skin Abnormalities collecting duct carcinoma sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma papillary renal cell carcinoma adrenal cortex carcinoma clear cell renal carcinoma hepatocellular carcinoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm renal carcinoma cancer transitional cell carcinoma renal cell carcinoma retinal detachment Skin Abnormalities collecting duct carcinoma sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma papillary renal cell carcinoma adrenal cortex carcinoma clear cell renal carcinoma hepatocellular carcinoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm renal carcinoma cancer exocrine pancreatic carcinoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia major depressive disorder osteosarcoma