3FHZ

Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ArgR regulatory domain-like	8064286	3000096	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ArgR regulatory domain-like	8064286	3000096	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ArgR regulatory domain-like	8064286	3000096	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ArgR regulatory domain-like	8064286	3000096	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ArgR regulatory domain-like	8064286	3000096	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ArgR regulatory domain-like	8064286	3000096	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arg_repressor	e3fhzA3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Arg_repressor	ECOD (1.6)
A	Arg_repressor_C	e3fhzA4	A: a+b two layers	X: Glucose permease domain IIB-like	H: arginine repressor C terminal domain-related	T: C-terminal domain of arginine repressor	F: Arg_repressor_C	ECOD (1.6)
B	Arg_repressor	e3fhzB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Arg_repressor	ECOD (1.6)
B	Arg_repressor_C	e3fhzB2	A: a+b two layers	X: Glucose permease domain IIB-like	H: arginine repressor C terminal domain-related	T: C-terminal domain of arginine repressor	F: Arg_repressor_C	ECOD (1.6)
C	Arg_repressor	e3fhzC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Arg_repressor	ECOD (1.6)
C	Arg_repressor_C	e3fhzC2	A: a+b two layers	X: Glucose permease domain IIB-like	H: arginine repressor C terminal domain-related	T: C-terminal domain of arginine repressor	F: Arg_repressor_C	ECOD (1.6)
D	Arg_repressor	e3fhzD3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Arg_repressor	ECOD (1.6)
D	Arg_repressor_C	e3fhzD1	A: a+b two layers	X: Glucose permease domain IIB-like	H: arginine repressor C terminal domain-related	T: C-terminal domain of arginine repressor	F: Arg_repressor_C	ECOD (1.6)
E	Arg_repressor	e3fhzE3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Arg_repressor	ECOD (1.6)
E	Arg_repressor_C	e3fhzE4	A: a+b two layers	X: Glucose permease domain IIB-like	H: arginine repressor C terminal domain-related	T: C-terminal domain of arginine repressor	F: Arg_repressor_C	ECOD (1.6)
F	Arg_repressor	e3fhzF3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Arg_repressor	ECOD (1.6)
F	Arg_repressor_C	e3fhzF4	A: a+b two layers	X: Glucose permease domain IIB-like	H: arginine repressor C terminal domain-related	T: C-terminal domain of arginine repressor	F: Arg_repressor_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
A	3.30.1360.40	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B	3.30.1360.40	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
C	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
C	3.30.1360.40	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
D	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
D	3.30.1360.40	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
E	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
E	3.30.1360.40	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
F	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
F	3.30.1360.40	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01316	Arginine repressor, DNA binding domain (Arg_repressor)	Arginine repressor, DNA binding domain	-	Domain
A, B, C, D, E A, B, C, D, E, F	PF02863	Arginine repressor, C-terminal domain (Arg_repressor_C)	Arginine repressor, C-terminal domain	This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization [1,2]. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.o ...	This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization [1,2]. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
H, J, L	5'-D(TPTPTPTPGPCPAPTPCPGPTPTPAPTPGPCPAPAPCPA)-3'	-	-	-
A, B, C, D, E A, B, C, D, E, F	Arginine repressor	DNA binding binding organic cyclic compound binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity cation binding organic acid binding ion binding anion binding amino acid binding carboxylic acid binding arginine binding small molecule binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis L-arginine biosynthetic process oxoacid metabolic process glutamine family amino acid biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis L-arginine biosynthetic process oxoacid metabolic process glutamine family amino acid biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process arginine metabolic process small molecule metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process metabolic process alpha-amino acid biosynthetic process regulation of cellular process regulation of arginine biosynthetic process regulation of amino acid biosynthetic process regulation of primary metabolic process regulation of small molecule metabolic process regulation of arginine metabolic process regulation of amino acid metabolic process regulation of biosynthetic process regulation of biological process biological regulation regulation of metabolic process regulation of glutamine family amino acid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm
G, I, K	5'-D(TPGPTPTPGPCPAPTPAPAPCPGPAPTPGPCPAPAPAPA)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001669	Arginine repressor	Family
A, B, C, D, E A, B, C, D, E, F	IPR020899	Arginine repressor, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR020900	Arginine repressor, DNA-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036251	Arginine repressor, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.