3CO1 | pdb_00003co1

Crystal structure of microtubule binding domain of human EB3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3co1a1	All alpha proteins	CH domain-like	Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3co1a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RP/EB family	8018823	4004023	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Calponin-homology domain, CH-domain	8051974	3000264	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CH	e3co1A1	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00307	Calponin homology (CH) domain (CH)	Calponin homology (CH) domain	The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1]. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its ac ...	The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1]. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity [4]. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin and Swiss:P15498 have only a single copy.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Microtubule-associated protein RP/EB family member 3	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding kinase binding enzyme binding protein kinase binding microtubule plus-end binding identical protein binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cell division regulation of cellular process positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cell division regulation of cellular process positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process cell cycle phosphorus metabolic process protein modification process positive regulation of protein phosphorylation regulation of biological process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cyclin-dependent protein kinase activity positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity regulation of cell cycle positive regulation of cellular process positive regulation of transferase activity biological regulation positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process positive regulation of cell cycle regulation of phosphorylation organelle assembly microtubule cytoskeleton organization membraneless organelle assembly spindle assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly microtubule-based process cellular component organization or biogenesis cytoskeleton organization chromosome segregation spindle organization cell cycle process regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of protein-containing complex assembly microtubule polymerization or depolymerization protein-containing complex assembly protein polymerization protein-containing complex organization regulation of microtubule-based process microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization regulation of microtubule polymerization regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of microtubule cytoskeleton organization protein localization to microtubule cytoskeleton protein localization to microtubule protein localization to cytoskeleton protein localization to organelle positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription	midbody cellular anatomical structure intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle midzone microtubule cytoskeleton polymeric cytoskeletal fiber mitotic spindle aster midbody cellular anatomical structure intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle midzone microtubule cytoskeleton polymeric cytoskeletal fiber mitotic spindle aster spindle microtubule cytoplasmic microtubule mitotic spindle astral microtubule end supramolecular polymer supramolecular complex microtubule end mitotic spindle astral microtubule astral microtubule supramolecular fiber cytoplasm microtubule microtubule plus-end microtubule organizing center perinuclear region of cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001715	Calponin homology domain	Domain
A	IPR004953	EB1, C-terminal	Domain
A	IPR027328	Microtubule-associated protein RP/EB	Family
A	IPR036133	EB1, C-terminal domain superfamily	Homologous Superfamily
A	IPR036872	CH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UPY8	polycystic ovary syndrome Abortion, Spontaneous atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian cancer Crohn disease large cell medulloblastoma medulloblastoma Pick disease psoriasis subependymal giant cell astrocytoma astrocytic tumor dermatomyositis lung carcinoma polycystic ovary syndrome Abortion, Spontaneous atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian cancer Crohn disease large cell medulloblastoma medulloblastoma Pick disease psoriasis subependymal giant cell astrocytoma astrocytic tumor dermatomyositis lung carcinoma oligodendroglioma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.