2WYN

Structure of family 37 trehalase from Escherichia coli in complex with a casuarine-6-O-a-D-glucoside analogue

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wyna_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	Trehalase-like	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d2wynb_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	Trehalase-like	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d2wynd_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	Trehalase-like	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d2wync_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	Trehalase-like	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Six-hairpin glycosidases	8034647	3000970	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Six-hairpin glycosidases	8034647	3000970	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Six-hairpin glycosidases	8034647	3000970	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Six-hairpin glycosidases	8034647	3000970	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trehalase	e2wynA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Trehalase	ECOD (1.6)
B	Trehalase	e2wynB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Trehalase	ECOD (1.6)
D	Trehalase	e2wynD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Trehalase	ECOD (1.6)
C	Trehalase	e2wynC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Trehalase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
B	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
D	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
C	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01204	Trehalase (Trehalase)	Trehalase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PERIPLASMIC TREHALASE	hydrolase activity, acting on glycosyl bonds alpha,alpha-trehalase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity trehalase activity catalytic activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process carbohydrate metabolic process trehalose catabolic process catabolic process trehalose metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process carbohydrate metabolic process trehalose catabolic process catabolic process trehalose metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process disaccharide metabolic process metabolic process disaccharide catabolic process response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus cellular response to chemical stimulus hyperosmotic response cellular hyperosmotic response response to chemical response to abiotic stimulus cellular response to abiotic stimulus	cellular anatomical structure outer membrane-bounded periplasmic space cell envelope periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR012341	Six-hairpin glycosidase-like superfamily	Homologous Superfamily
A, B, C, D	IPR018232	Glycoside hydrolase, family 37, conserved site	Conserved Site
A, B, C, D	IPR001661	Glycoside hydrolase, family 37	Family
A, B, C, D	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily
A, B, C, D	IPR023720	Trehalase, periplasmic	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.