2RDA
Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | Thymidylat_synt | e2rdaC1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
D | Thymidylat_synt | e2rdaD1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
E | Thymidylat_synt | e2rdaE1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
A | Thymidylat_synt | e2rdaA1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
B | Thymidylat_synt | e2rdaB1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
F | Thymidylat_synt | e2rdaF1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
D | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
E | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
A | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
B | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
F | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily | Homologous Superfamily | |
IPR000398 | Thymidylate synthase | Family | |
IPR020940 | Thymidylate synthase, active site | Active Site | |
IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain | Domain | |
IPR045097 | Thymidylate synthase/dCMP hydroxymethylase | Family |