Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Cd2rdac_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2rdad_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed2rdae_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad2rdaa_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2rdab_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd2rdaf_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
CThymidylat_synte2rdaC1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
DThymidylat_synte2rdaD1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
EThymidylat_synte2rdaE1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
AThymidylat_synte2rdaA1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
BThymidylat_synte2rdaB1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
FThymidylat_synte2rdaF1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
D3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
E3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
A3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
B3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
F3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Thymidylate synthase

InterPro: Protein Family Classification InterPro Database Homepage

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D, E
PharosP04818