2QY7

Crystal structure of human epsinR ENTH domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ENTH domain	8067879	4001355	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ENTH/VHS domain-like	8067880	3000164	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	ENTH/VHS domain-like	8067880	3000164	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ENTH/VHS domain-like	8067880	3000164	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ENTH	e2qy7A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ENTH	ECOD (1.6)
C	ENTH	e2qy7C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ENTH	ECOD (1.6)
B	ENTH	e2qy7B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ENTH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
C	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
B	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01417	ENTH domain (ENTH)	ENTH domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Clathrin interactor 1	clathrin binding protein binding binding cell adhesion molecule binding cadherin binding phospholipid binding lipid binding	clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis localization import into cell transport endocytosis establishment of localization vesicle-mediated transport	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system endosome intracellular vesicle cytoplasmic vesicle vesicle cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system endosome intracellular vesicle cytoplasmic vesicle vesicle cytosol perinuclear region of cytoplasm cell periphery plasma membrane protein-containing complex vesicle coat membrane protein complex membrane coat bounding membrane of organelle vesicle membrane clathrin-coated vesicle clathrin vesicle coat coated vesicle clathrin-coated vesicle membrane coated membrane clathrin coat coated vesicle membrane cytoplasmic vesicle membrane organelle membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR008942	ENTH/VHS	Homologous Superfamily
A, B, C	IPR013809	ENTH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q14677	atypical teratoid rhabdoid tumor glioblastoma lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis breast cancer large cell medulloblastoma malignant ependymoma ovarian cancer plasma cell myeloma cystic fibrosis lung adenocarcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor glioblastoma lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis breast cancer large cell medulloblastoma malignant ependymoma ovarian cancer plasma cell myeloma cystic fibrosis lung adenocarcinoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.