2N90 | pdb_00002n90

TrkA transmembrane domain NMR structure in DPC micelles

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF08790	e2n90A1	A: extended segments	X: Transmembrane segment of lysosome-associated membrane glycoprotein 2 (From Topology)	H: Transmembrane segment of lysosome-associated membrane glycoprotein 2 (From Topology)	T: Transmembrane segment of lysosome-associated membrane glycoprotein 2	F: EUF08790	ECOD (1.6)
B	EUF08790	e2n90B1	A: extended segments	X: Transmembrane segment of lysosome-associated membrane glycoprotein 2 (From Topology)	H: Transmembrane segment of lysosome-associated membrane glycoprotein 2 (From Topology)	T: Transmembrane segment of lysosome-associated membrane glycoprotein 2	F: EUF08790	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF18613	Tyrosine kinase receptor A trans-membrane domain (TrkA_TMD)	Tyrosine kinase receptor A trans-membrane domain	This receptor consists of 796 amino acids and can be divided in the extracellular ligand-binding domain, the trans-membrane domain, and the intracellular tyrosine kinase domain [1].This domain is the TMD of TrkA which has shown to be involved in the ...	This receptor consists of 796 amino acids and can be divided in the extracellular ligand-binding domain, the trans-membrane domain, and the intracellular tyrosine kinase domain [1].This domain is the TMD of TrkA which has shown to be involved in the interaction with amyloid precursor protein (APP) [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	High affinity nerve growth factor receptor	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity neurotrophin binding protein binding binding nerve growth factor binding growth factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity brain-derived neurotrophic factor receptor activity neurotrophin receptor activity hepatocyte growth factor receptor activity nerve growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity identical protein binding protein homodimerization activity protein dimerization activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity histone H3Y41 kinase activity histone H3 kinase activity placental growth factor receptor activity signaling receptor binding cytokine receptor binding neurotrophin receptor binding neurotrophin p75 receptor binding insulin-like growth factor receptor activity boss receptor activity epidermal growth factor receptor activity kinase binding enzyme binding fibroblast growth factor receptor activity	response to stimulus response to chemical response to xenobiotic stimulus regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization response to stimulus response to chemical response to xenobiotic stimulus regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization detection of external stimulus system process detection of stimulus involved in sensory perception of pain nervous system process response to external stimulus sensory perception of temperature stimulus sensory perception of pain detection of temperature stimulus involved in sensory perception response to temperature stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of temperature stimulus response to abiotic stimulus detection of stimulus involved in sensory perception detection of temperature stimulus involved in sensory perception of pain protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process cellular response to stimulus cellular response to growth factor stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cellular response to nerve growth factor stimulus cell communication cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor response to growth factor signal transduction rhythmic process circadian rhythm positive regulation of nervous system development regulation of developmental process regulation of nervous system development positive regulation of developmental process cellular component biogenesis cellular component assembly cell junction assembly regulation of multicellular organismal process regulation of synapse structure or activity synapse organization regulation of synapse assembly regulation of biological quality regulation of multicellular organismal development positive regulation of cellular component biogenesis regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly detection of mechanical stimulus involved in sensory perception of pain response to mechanical stimulus detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of mechanical stimulus positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic synaptic signaling trans-synaptic signaling positive regulation of synaptic transmission cell-cell signaling positive regulation of synaptic transmission, glutamatergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity mechanoreceptor differentiation cellular response to chemical stimulus cellular response to nicotine response to nicotine neuron apoptotic process axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis axon guidance axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection guidance neurotrophin TRK receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of programmed cell death multicellular organismal response to stress response to pain behavior behavioral response to formalin induced pain response to stress chemosensory behavior behavioral response to chemical pain behavioral response to pain protein autophosphorylation peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation peptidyl-amino acid modification peptidyl-tyrosine phosphorylation response to wounding response to axon injury spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation sympathetic nervous system development autonomic nervous system development response to electrical stimulus positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process programmed cell death involved in cell development response to nutrient levels sex differentiation epithelial cell differentiation Sertoli cell differentiation male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development epithelium development gonad development reproductive system development Sertoli cell development animal organ development tissue development epithelial cell development hemopoiesis B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of neuron apoptotic process regulation of neuron apoptotic process olfactory nerve development nerve development cranial nerve development negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis learning or memory cognition positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process regulation of phosphorus metabolic process regulation of phosphorylation response to acid chemical response to hydrostatic pressure response to oxygen-containing compound response to water innervation axonogenesis involved in innervation small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of small GTPase mediated signal transduction	membrane-bounded organelle endosome membrane intracellular anatomical structure endosome membrane intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle membrane-bounded organelle endosome membrane intracellular anatomical structure endosome membrane intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle late endosome cytoplasm vesicle organelle membrane protein-containing complex receptor complex cell surface cell periphery plasma membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body axon mitochondrion early endosome recycling endosome recycling endosome membrane early endosome membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR020777	Growth factor receptor NTRK	Family
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR020461	High affinity nerve growth factor receptor NTRK1	Family
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR031635	Growth factor receptor NTRK, leucine rich repeat C-terminal	Domain
A, B	IPR040665	Tyrosine kinase receptor A, transmembrane domain	Domain
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR050122	Receptor Tyrosine Kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P04629	hereditary sensory and autonomic neuropathy type 4 familial medullary thyroid carcinoma malignant glioma neuroblastoma schizoaffective disorder Lewy body dementia neuralgia hereditary sensory and autonomic neuropathy schizophrenia Lung Injury mixed glioma bipolar disorder cancer medulloblastoma Charcot-Marie-Tooth disease hereditary sensory and autonomic neuropathy type 4 familial medullary thyroid carcinoma malignant glioma neuroblastoma schizoaffective disorder Lewy body dementia neuralgia hereditary sensory and autonomic neuropathy schizophrenia Lung Injury mixed glioma bipolar disorder cancer medulloblastoma Charcot-Marie-Tooth disease ovarian serous adenocarcinoma psoriasis hypothyroidism thyroid gland papillary carcinoma non-small cell lung carcinoma glioma hereditary sensory and autonomic neuropathy type 1 hereditary sensory and autonomic neuropathy type 5 Riley-Day syndrome schizophreniform disorder intellectual disability sensory peripheral neuropathy colorectal adenocarcinoma digestive system disease Hashimoto thyroiditis hereditary sensory and autonomic neuropathy type 2

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Bitopic proteins	Receptor-type kinases	Protein tyrosine kinases

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.