Annotations: 2MX2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ubiquitin_4	e2mx2A1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: ubiquitin_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21403	OTU1, UBXL domain (OTU1_UBXL)	OTU1, UBXL domain	OTU1 is a deubiquitinating enzyme that may play an important regulatory role at the level of protein turnover by preventing degradation. This entry represents the ubiquitin regulatory X-like (UBXL) which interacts with the N-terminal domain of VCP [1 ...	OTU1 is a deubiquitinating enzyme that may play an important regulatory role at the level of protein turnover by preventing degradation. This entry represents the ubiquitin regulatory X-like (UBXL) which interacts with the N-terminal domain of VCP [1] and removes ubiquitin chains using the OTU domain. This domain is also found in VCIP1, a known UBXL-containing protein that functions in p97/p47-mediated Golgi reassembly.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Deubiquitinating protein VCIP135	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process protein-DNA covalent cross-linking repair metabolic process macromolecule metabolic process DNA repair cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process protein-DNA covalent cross-linking repair metabolic process macromolecule metabolic process DNA repair protein deubiquitination protein K11-linked deubiquitination protein modification by small protein removal macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal protein K48-linked deubiquitination membrane organization membrane fusion organelle membrane fusion endoplasmic reticulum organization cellular component organization organelle fusion organelle organization endoplasmic reticulum membrane organization cellular component organization or biogenesis endoplasmic reticulum membrane fusion endomembrane system organization protein localization regulation of localization regulation of biological process cellular localization protein localization to chromatin regulation of cellular process regulation of protein localization biological regulation localization protein localization to chromosome regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle regulation of protein localization to chromatin protein ubiquitination protein modification by small protein conjugation proteolysis Golgi inheritance organelle inheritance Golgi reassembly cellular component biogenesis cellular component assembly Golgi organization	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm synapse cell junction membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm synapse cell junction nucleus endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR039087	Deubiquitinating protein VCPIP1	Family
A	IPR003323	OTU domain	Domain
A	IPR045827	Deubiquitinating protein VCPIP1, N-terminal	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR048857	OTU1, Ubl domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.