2M38 | pdb_00002m38

PTB domain of AIDA1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2m38a_	All beta proteins	PH domain-like barrel	PH domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PID	e2m38A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00640	Phosphotyrosine interaction domain (PTB/PID) (PID)	Phosphotyrosine interaction domain (PTB/PID)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	protein binding binding signaling receptor binding ephrin receptor binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular process signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway	membrane-bounded organelle Cajal body intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle Cajal body intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite dendritic tree cytoplasm cytosol postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002110	Ankyrin repeat	Repeat
A	IPR006020	PTB/PI domain	Domain
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR041880	Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001660	Sterile alpha motif domain	Domain
A	IPR033635	Ankyrin repeat and SAM domain-containing protein 1/Caskin	Family
A	IPR041882	Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q7Z6G8	Wilson disease adenoma bipolar disorder Hepatic Form of Wilson Disease lung carcinoma medulloblastoma pilocytic astrocytoma astrocytic tumor drug dependence heroin dependence malignant ependymoma oligodendroglioma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma Wilson disease adenoma bipolar disorder Hepatic Form of Wilson Disease lung carcinoma medulloblastoma pilocytic astrocytoma astrocytic tumor drug dependence heroin dependence malignant ependymoma oligodendroglioma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.