2LSJ | pdb_00002lsj

Solution structure of the mouse Rev1 CTD in complex with the Rev1-interacting Region (RIR)of Pol Kappa

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DNA repair protein REV1 C-terminal domain-like	8091496	3002514	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e2lsjA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA repair protein Rev1 C-terminal domain (From Topology)	T: DNA repair protein Rev1 C-terminal domain	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.1280	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16727	DNA repair protein REV1 C-terminal domain (REV1_C)	DNA repair protein REV1 C-terminal domain	This is the C-terminal domain of DNA repair protein REV1. It interacts with REV7, POLN, POLK and POLI [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA repair protein REV1	deoxycytidyl transferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid DNA binding binding damaged DNA binding nucleic acid binding cation binding deoxycytidyl transferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid DNA binding binding damaged DNA binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	translesion synthesis cellular response to stimulus postreplication repair response to stimulus primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process DNA synthesis involved in DNA repair macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process cellular response to stress biosynthetic process DNA damage response translesion synthesis cellular response to stimulus postreplication repair response to stimulus primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process DNA synthesis involved in DNA repair macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process cellular response to stress biosynthetic process DNA damage response response to stress metabolic process cellular process error-prone translesion synthesis macromolecule metabolic process DNA biosynthetic process DNA repair response to light stimulus response to radiation response to abiotic stimulus response to UV	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
B	DNA polymerase kappa	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups molecular adaptor activity DNA binding binding damaged DNA binding nucleic acid binding cation binding catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups molecular adaptor activity DNA binding binding damaged DNA binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process DNA replication metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process translesion synthesis cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process DNA replication metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process translesion synthesis postreplication repair nucleobase-containing compound biosynthetic process DNA synthesis involved in DNA repair macromolecule biosynthetic process nucleic acid biosynthetic process biosynthetic process error-prone translesion synthesis DNA biosynthetic process DNA repair response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV nucleotide-excision repair, DNA gap filling nucleotide-excision repair	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle site of DNA damage intracellular membraneless organelle chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR047346	DNA repair protein REV1, ubiquitin-binding motif 1/2	Conserved Site
A	IPR031991	DNA repair protein Rev1, C-terminal	Domain
A	IPR001126	UmuC domain	Domain
A	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A	IPR036775	DNA polymerase, Y-family, little finger domain superfamily	Homologous Superfamily
A	IPR012112	DNA repair protein Rev1	Family
A	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A	IPR025527	HUWE1/REV1, ubiquitin-binding motif	Conserved Site
A	IPR038401	Rev1, C-terminal domain superfamily	Homologous Superfamily
A	IPR001357	BRCT domain	Domain
A	IPR017961	DNA polymerase, Y-family, little finger domain	Domain
A	IPR053848	DNA polymerase IV/DNA polymerase iota-like, thumb domain	Domain
A	IPR036420	BRCT domain superfamily	Homologous Superfamily
B	IPR001126	UmuC domain	Domain
B	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
B	IPR036775	DNA polymerase, Y-family, little finger domain superfamily	Homologous Superfamily
B	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
B	IPR050116	DNA polymerase type-Y	Family
B	IPR022880	DNA polymerase IV	Family
B	IPR017961	DNA polymerase, Y-family, little finger domain	Domain
B	IPR006642	Rad18, zinc finger UBZ4-type	Domain