2LNW | pdb_00002lnw

Identification and structural basis for a novel interaction between Vav2 and Arap3

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH2 domain	8067972	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH2	e2lnwA1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Guanine nucleotide exchange factor VAV2	phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides small molecule binding epidermal growth factor receptor binding signaling receptor binding growth factor receptor binding cation binding metal ion binding	lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly developmental process multicellular organismal process blood vessel morphogenesis lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development regulation of cellular component size biological regulation regulation of biological quality regulation of cell size regulation of anatomical structure size cellular response to stimulus positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling cell migration cell motility regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation response to wounding platelet activation immune response-regulating cell surface receptor signaling pathway cell surface receptor signaling pathway immune response Fc receptor signaling pathway immune response-regulating signaling pathway immune system process Fc-epsilon receptor signaling pathway regulation of immune response regulation of immune system process small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction cellular response to chemical stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity cell surface receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway immune response-regulating cell surface receptor signaling pathway involved in phagocytosis import into cell transport Fc-gamma receptor signaling pathway involved in phagocytosis vesicle-mediated transport localization immune response-activating signaling pathway positive regulation of immune response phagocytosis Fc-gamma receptor signaling pathway positive regulation of immune system process immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway establishment of localization immune effector process endocytosis activation of immune response	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane
B	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	ion binding binding anion binding phosphatidylinositol-3,4-bisphosphate binding small molecule binding phosphatidylinositol-3,4,5-trisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding cation binding metal ion binding	regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of actin filament-based process actin cytoskeleton organization biological regulation regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of actin filament-based process actin cytoskeleton organization biological regulation regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus response to stimulus signaling signal transduction cell communication localization transport establishment of localization vesicle-mediated transport	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery plasma membrane membrane intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery plasma membrane membrane intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle ruffle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR035733	VAV2 protein, first SH3 domain	Domain
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR000219	Dbl homology domain	Domain
A	IPR001715	Calponin homology domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR035732	VAV2 protein, second SH3 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
A	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A	IPR035880	VAV2, SH2 domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR036872	CH domain superfamily	Homologous Superfamily
A	IPR022613	Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain	Domain
A	IPR037832	Vav, PH domain	Domain
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR055251	SOS1/NGEF-like, PH domain	Domain
B	IPR052227	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein	Family
B	IPR001849	Pleckstrin homology domain	Domain
B	IPR011993	PH-like domain superfamily	Homologous Superfamily
B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
B	IPR038508	ArfGAP domain superfamily	Homologous Superfamily
B	IPR000198	Rho GTPase-activating protein domain	Domain
B	IPR000159	Ras-associating domain	Domain
B	IPR037858	ARAP, RhoGAP domain	Domain
B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
B	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B	IPR001164	Arf GTPase activating protein	Domain
B	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P52735	breast carcinoma osteosarcoma pituitary cancer gastric carcinoma ovarian cancer primitive neuroectodermal tumor malignant colon neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
B	Pharos: Q8WWN8	HIV infectious disease colorectal cancer HIV Coinfection lung cancer medulloblastoma ovarian cancer diffuse large B-cell lymphoma malignant glioma non-small cell lung carcinoma primitive neuroectodermal tumor glioblastoma lung adenocarcinoma osteosarcoma