Annotations: 2KBB

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	talin-RS	e2kbbA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: talin-RS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1420.10	Mainly Alpha	Up-down Bundle	A middle domain of Talin 1	Talin, central domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21865	Talin 1-like, rod segment domain (TLN1-like_RS)	Talin 1-like, rod segment domain	This domain is found repeated in human Talin-1 (TLN1) and similar proteins mainly found in animals. Talin is an essential component in focal adhesions (FAs), intracellular protein assemblies that serve as tension-sensing anchoring points to link cell ...	This domain is found repeated in human Talin-1 (TLN1) and similar proteins mainly found in animals. Talin is an essential component in focal adhesions (FAs), intracellular protein assemblies that serve as tension-sensing anchoring points to link cells to the extracellular environment. This protein plays a key regulatory role in FA dynamics, similar to the activation and inactivation of integrins. It consists of a globular head, a long rod made of 62 helices forming 13 helical bundle (rod segment, RS) domains, and a dimerisation (DD) motif at the C terminus. This entry represents four of these domains, RS 5, 6, 9 and 11 [6,7].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Talin-1	binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding LIM domain binding protein domain specific binding vinculin binding cell adhesion molecule binding integrin binding binding phospholipid binding lipid binding phosphatidylinositol binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding LIM domain binding protein domain specific binding vinculin binding cell adhesion molecule binding integrin binding signaling receptor binding structural constituent of cytoskeleton structural molecule activity modified amino acid binding phosphatidylserine binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process integrin activation cellular component organization or biogenesis cortical cytoskeleton organization microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization organelle organization microtubule-based process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process integrin activation cellular component organization or biogenesis cortical cytoskeleton organization microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization organelle organization microtubule-based process supramolecular fiber organization cytoskeleton organization cellular response to stimulus regulation of biological process integrin-mediated signaling pathway regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication signal transduction cell junction organization cell junction assembly cell-substrate junction assembly cell-substrate junction organization actin cytoskeleton organization cortical actin cytoskeleton organization actin filament-based process cell adhesion	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane cell surface intracellular anatomical structure cytoplasm cell-cell junction adherens junction intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR002404	IRS-type PTB domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR015009	Vinculin-binding site-containing domain	Domain
A	IPR032425	Talin, N-terminal F0 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A	IPR015224	Talin, central	Domain
A	IPR054082	Talin, IBS2B domain	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR036476	Talin, central domain superfamily	Homologous Superfamily
A	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A	IPR002558	I/LWEQ domain	Domain
A	IPR019747	FERM conserved site	Conserved Site
A	IPR054060	Talin 1-like, rod-segment domain	Domain
A	IPR049108	Talin, R4 domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR037438	Talin-1/2, rod-segment	Domain