2IGO

Crystal structure of pyranose 2-oxidase H167A mutant with 2-fluoro-2-deoxy-D-glucose

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth D]	d2igod1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
C [auth D]	d2igod2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
H [auth G]	d2igog1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
H [auth G]	d2igog2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
A	d2igoa1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
A	d2igoa2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
B	d2igob1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
B	d2igob2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
D [auth C]	d2igoc1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
D [auth C]	d2igoc2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
E	d2igoe1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
E	d2igoe2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
F	d2igof1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
F	d2igof2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
G [auth H]	d2igoh1	Alpha and beta proteins (a/b)	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	FAD-linked reductases, N-terminal domain	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)
G [auth H]	d2igoh2	Alpha and beta proteins (a+b)	FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	GMC oxidoreductases	Pyranose 2-oxidase	(Trametes ochracea ) [TaxId: 230624 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth D]	pyranose_ox	e2igoD1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
C [auth D]	GMC_oxred_N	e2igoD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
H [auth G]	pyranose_ox	e2igoG1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
H [auth G]	GMC_oxred_N	e2igoG2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
A	pyranose_ox	e2igoA1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
A	GMC_oxred_N	e2igoA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
B	pyranose_ox	e2igoB1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
B	GMC_oxred_N	e2igoB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
D [auth C]	pyranose_ox	e2igoC1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
D [auth C]	GMC_oxred_N	e2igoC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
E	pyranose_ox	e2igoE1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
E	GMC_oxred_N	e2igoE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
F	pyranose_ox	e2igoF1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
F	GMC_oxred_N	e2igoF2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)
G [auth H]	pyranose_ox	e2igoH1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: pyranose_ox	ECOD (1.6)
G [auth H]	GMC_oxred_N	e2igoH2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: GMC_oxred_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth D]	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
H [auth G]	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
A	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
B	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
D [auth C]	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
E	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
F	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)
G [auth H]	3.30.1920.50	Alpha Beta	2-Layer Sandwich	Phage tail proteins - 2 layer sandwich fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth C], E, A, B, C [auth D], D [auth C], E, F, G [auth H], H [auth G]	PF05199	GMC oxidoreductase (GMC_oxred_C)	GMC oxidoreductase	This domain found associated with Pfam:PF00732.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth C], E, A, B, C [auth D], D [auth C], E, F, G [auth H], H [auth G]	Pyranose oxidase	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors pyranose oxidase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	-	cellular anatomical structure periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth C], E, A, B, C [auth D], D [auth C], E, F, G [auth H], H [auth G]	IPR012814	Pyranose 2-oxidase	Family
A, B, C [auth D], D [auth C], E, A, B, C [auth D], D [auth C], E, F, G [auth H], H [auth G]	IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal	Domain
A, B, C [auth D], D [auth C], E, A, B, C [auth D], D [auth C], E, F, G [auth H], H [auth G]	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth C], E, A, B, C [auth D], D [auth C], E, F, G [auth H], H [auth G]	IPR051473	Pyranose 2-oxidase-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.