2H7D

Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8043603	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IRS_1	e2h7dA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: IRS_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02174	PTB domain (IRS-1 type) (IRS)	PTB domain (IRS-1 type)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Talin-1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cell adhesion molecule binding integrin binding signaling receptor binding structural constituent of cytoskeleton structural molecule activity	cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization cell adhesion cell-cell adhesion	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane cell surface intracellular anatomical structure cytoplasm cytosol intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle
B	Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma	cytoskeletal protein binding protein binding binding talin binding 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding cytoskeletal protein binding protein binding binding talin binding 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis biological regulation platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation regulation of localization cellular localization regulation of cellular process regulation of cellular component organization synaptic vesicle cycle regulation of synaptic vesicle recycling presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell cellular component organization or biogenesis regulation of endocytosis synaptic vesicle endocytosis regulation of biological process regulation of transport regulation of vesicle-mediated transport phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development chemotaxis taxis response to chemical response to external stimulus locomotion secretion by cell exocytosis secretion export from cell receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization regulation of postsynaptic neurotransmitter receptor internalization regulation of receptor-mediated endocytosis protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis receptor-mediated endocytosis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm cytosol synapse glutamatergic synapse cell-cell junction adherens junction uropod cell trailing edge postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle asymmetric synapse endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane phagocytic cup

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR002404	IRS-type PTB domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR015009	Vinculin-binding site-containing domain	Domain
A	IPR032425	Talin, N-terminal F0 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A	IPR015224	Talin, central	Domain
A	IPR054082	Talin, IBS2B domain	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR036476	Talin, central domain superfamily	Homologous Superfamily
A	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A	IPR002558	I/LWEQ domain	Domain
A	IPR019747	FERM conserved site	Conserved Site
A	IPR054060	Talin 1-like, rod-segment domain	Domain
A	IPR018979	FERM, N-terminal	Domain
A	IPR049108	Talin, R4 domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR037438	Talin-1/2, rod-segment	Domain
B	IPR027483	Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily	Homologous Superfamily
B	IPR002498	Phosphatidylinositol-4-phosphate 4/5-kinase, core	Domain
B	IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal	Homologous Superfamily
B	IPR023610	Phosphatidylinositol-4/5-phosphate 5/4-kinase	Family