2FY2

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2fy2a2	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	Choline/Carnitine O-acyltransferase	Choline O-acetyltransferase, C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2fy2a1	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	Choline/Carnitine O-acyltransferase	Choline O-acetyltransferase, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carn_acyltransf_2nd	e2fy2A3	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Carn_acyltransf_2nd	ECOD (1.6)
A	Carn_acyltransf_1st	e2fy2A4	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Carn_acyltransf_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
A	3.30.559.70	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Choline/Carnitine o-acyltransferase, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00755	Choline/Carnitine o-acyltransferase (Carn_acyltransf)	Choline/Carnitine o-acyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Choline O-acetyltransferase	choline O-acetyltransferase activity acetyltransferase activity O-acyltransferase activity acyltransferase activity O-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity	localization transport neurotransmitter transport establishment of localization glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process localization transport neurotransmitter transport establishment of localization glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process glycerolipid metabolic process metabolic process cellular process phosphatidylcholine biosynthetic process phosphorus metabolic process lipid metabolic process acetate ester biosynthetic process acetate ester metabolic process acetylcholine biosynthetic process acetylcholine metabolic process trans-synaptic signaling regulation of biological process signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission	cellular anatomical structure synapse cell junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000542	Acyltransferase ChoActase/COT/CPT	Family
A	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily	Homologous Superfamily
A	IPR039551	Choline/carnitine acyltransferase domain	Domain
A	IPR042231	Choline/Carnitine o-acyltransferase, domain 2	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P28329	congenital myasthenic syndrome congenital myasthenic syndrome 6 retinal disease visual epilepsy angle-closure glaucoma Jacksonian Seizure neurodegenerative disease primary angle-closure glaucoma arthrogryposis depressive disorder Hodgkins lymphoma peripheral nervous system disease psoriasis schizophrenia ischemia reperfusion injury congenital myasthenic syndrome congenital myasthenic syndrome 6 retinal disease visual epilepsy angle-closure glaucoma Jacksonian Seizure neurodegenerative disease primary angle-closure glaucoma arthrogryposis depressive disorder Hodgkins lymphoma peripheral nervous system disease psoriasis schizophrenia ischemia reperfusion injury peripheral neuropathy dementia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.